Diseases that may be related via low vitamin D

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Disease associated with low vitamin D increases the probability of another low D disease

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Vitamin D levels must be restored to reduce the risk of many associated diseases

Diseases listed in the above graphic:
Prostate cancer, Breast cancer, Bladder cancer, Skin Cancer, Osteoporosis, Rickets, MS, Falls/fractures, Diabetes, Influenza, Kidney, Depression, Chronic fatigue, Birth problems, SAD, Pancreas, Overweight, Heart disease, Lupus, Chronic Pain, ALS, TB, IBD, COPD, Colds, Cognitive Decline, Psoriasis, Bone density/fractures

Comorbidity (medical term): the presence of one or more additional disorders co-occurring with a primary disorder

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Perplexity AI Deep Research on disease associations based in this page and the internet as of Feb 2025

Question I want to find which vitamin D-related diseases increase the risk of other vitamin D-related diseases. Please use the attached 91 pairs of associations but look elsewhere as well. It would be nice if you could report on the strenght of the association as well. ( example: Disease X increases the risk of Disease Y by 5x)

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92+ Disease Associations

92+ Disease associations:   Disease 1 ==> Disease 2 (both associated with low vitamin D

• Statins ==> many diseases associated with low vitamin D  update Jan 2012
• Parkinson, Alzheimer, Stroke ==>Hip fracture
• Parkinson's ==> Osteoporosis
• Low Grip Strength ==> Osteoporosis
• Immune System disease (CVID) ==> Osteoporosis
• COPD ==> Osteoporosis
• COPD ==> Bone Fracture 4.7 X
• COPD ==> osteoporosis, cardio., skeletal muscle, anemia, metabolic synd.
• HIV ==> Osteoporosis
• Cancer - Prostate ==> Osteoporosis
• Cancer - Prostate ==> Melanoma
• Cancer - Gynecological ==> Atherosclerosis
• Atopic Dermatitis ==> Osteopenia 1.8 X
• Alopecia Areata spot baldness ==> 5X higher risk of Lupus, vitiligo, metabolic syndrome
• Skin wrinkles ==> Fragile bones
• Depression ==> Fragile bones
• Depression ==> Osteoporosis
• Depressed ==> Stroke 1.7X
• Depression ==> Heart Disease 1.4X

• Depression + Stroke ==> death 3X
• Depression ==> premature birth
    96% increase in premature birth if anti-depressants in late pregnancy
• Depression ==> Cognitive Decline
• Depression <==> Diabetes
• Acne ==> Depression
• Diabetes ==> Cognitive impairment
• Diabetes ==> Vertebral fracture in men only
• Diabetes ==> Rheumatoid Arthritis
• Diabetes ==> PCOS women
• PCOS ==> Diabetes
• Asthma ==> Diabetes 10X
• ear, nose, and throat infection ==> Diabetes 10X
• Periodontitis + Low Vit D ==> Diabetes 2.8X
• Obesity ==> Diabetes
• Diabetes ==> Pancreatic Cancer
• Diabetes ==> Cancers
• Diabetes ==> Alzheimer's
• Diabetes ==> TB?
• Diabetes (T1) ==> Multiple Sclerosis
• Diabetes ==> Parkinson's
• Smoking ==> weak bones
• Dental problems==> depression (pregnancy)
• Endometriosis ==> Coronary Heart Disease 3X
• Pregnancy ==> dental problems
• Pregnancy ==>Restless Legs
• No molar ==> 12X increase in Breast Cancer
• Obesity <==> Multiple Sclerosis
• Obesity ==> Cognitive Decline
• Obesity ==> Psorasis
• Obesity ==> Cancer
• Obesity ==> Migraine Headache 3X
• Aortic calcification==> Vertebral fracture
• Low vitamin D for various reasons ==> 9X Suicide
• Asthma ==> Heart Problems and death
• Kidney ==> Tooth loss 7X
• Kidney ==> Parkinson's 4X
• Kidney Disease ==> Osteoporosis 2014
• Multiple Sclerosis ==> Asthma 3X
• Multiple Sclerosis ==> 2.6X increased Migrane Headache, web, full text online
• Multiple Sclerosis ==> Fractures 4X
• Multiple Sclerosis ==> Fibromyalgia
• Multiple Sclerosis ==> Osteporosis
• Multiple Sclerosis ==> Diabetes (T1)
• Psoriasis ==> Metabolic Syndrome on the web
• Psoriasis ==> Metabolic Syndrome
• Psoriasis ==> Kidney Disease
• Psoriasis ==> Heart problems
• Psoriasis ==> Diabetes
• Psoriasis==> Osteoporosis
• Psoriasis ==> Sleep Apnea
• Celiac Disease ==> Anemia, Psoriasis
• Celiac Disease ==> poor bones Aug 2014
• Intestinal Failure (gut) ==> Low Bone Mineral Density
• Chronic Pancreatitis ==>Painful bones
• Rheumatoid Arthritis ==> Cardiovascular
• Rheumatoid Arthritis ==>Psorasis 3.6X
• IBD ==> Cancer
• Stroke ==> Hip Fracture
• Stroke ==> Parkinson's Disease 2.4X
• Restless Legs <==> ADHD
• Schizophrenia ==> Depression
• Schizophrenia ==> Diabetes 3X
• Sleep Apnea ==>Fatty Liver disease
• Sleep Apnea ==>Gout
• Gout ==> Depression 3.8 X
• Hepatitis-C ==> Cancers - liver, prostate, ?
• Hepatitis -C ==> peripheral arterial disease 12X increase if > 65 years old
• Vitiligo ==> thyroid problems 2013
• Rickets ==> Autism
• Autism ==> Poor Bones
• Epilepsy ==> Osteoporosis
• Rickets ==> Breathing
• Lupus ==>preterm birth

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Most of these problems can be reduced by getting more Vitamin D, or

• Sunlight
• UV
• Sublingual, injection, bio-emulsified or other forms of vitamin D which do not require the gut
• Adding a lot more vitamin D than a healthy person would need

CLICK ON chart for more information

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See also VitaminDWiki

• Criteria to associate a health problem with low vitamin D
• 3 to 55 X more likely to have these health problems if low Vitamin D
• Health problems that run in families are often associated with low vitamin D
• Incidence of 22 health problems related to vitamin D have doubled in a decade

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