Methylation of the Vitamin D Receptor Gene in Human Disorders
Int. J. Mol. Sci. 2024, 25(1), 107; https://doi.org/10.3390/ijms25010107
by Beatrice Gasperini 1,†,Angela Falvino 1,†,Eleonora Piccirilli 2,Umberto Tarantino 2ORCID,Annalisa Botta 1,*ORCID and Virginia Veronica Visconti 1ORCID
1 Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
2 Department of Clinical Sciences and Translational Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH)2D3), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the VDR gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of VDR methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer, and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases.
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VDR associated Diseases searched for include:
- “VDR methylation in autoimmune diseases”,
- “VDR methylation AND Rheumatoid Arthritis”,
- “VDR methylation AND Multiple Sclerosis”,
- “VDR methylation AND Bechet’s disease”,
- “VDR methylation in infectious diseases”,
- “VDR methylation AND Tuberculosis disease”,
- “VDR methylation AND Hand Foot and Mouth disease”,
- “VDR methylation AND HIV”,
- “VDR methylation in cancer”,
- “VDR gene methylation AND breast cancer”,
- “VDR methylation AND Adrenocortical carcinoma”,
- “VDR methylation AND Hepatocellular carcinoma”,
- “VDR methylation AND Parathyroid adenomas”,
- “VDR methylation AND colorectal cancer”,
- “VDR methylation AND Osteoporosis”,
- “VDR methylation AND Male infertility”,
- “VDR methylation AND Recurrent Kidney stone formation”,
- “VDR methylation AND Type 2 Diabetes Mellitus”.
VitaminDWiki – Cancer increases if poor Vitamin D Receptor
Cancers get less Vitamin D when there is a poor Vitamin D Receptor
- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor (Cancers OR Viruses) - many studies
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
| 23 |
articles
- Breast Cancer and VDR
| 24 |
articles
- Colon Cancer and VDR
| 14 |
articles
- Prostate Cancer and VDR
| 7 |
articles
- Skin Cancer and VDR
| 10 |
articles
- Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation
39+ VitaminDWiki Mortality pages have CANCER in the title
This list is automatically updated
Items found: 40
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US Cancer statistics - Jan 2025 |
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19 Feb, 2025 |
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Pancreatic cancer mortality 28% more likely if low vitamin D – meta-analysis Jan 2024 |
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28 Nov, 2024 |
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3 Cancers have higher mortality if high PTH (which can be lowered by Vitamin D) - Aug 2024 |
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15 Aug, 2024 |
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Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024 |
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01 May, 2024 |
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People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023 |
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23 Nov, 2023 |
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Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 |
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31 Jul, 2023 |
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Cancer incidence or mortality not changed by small Vitamin D doses: 2021-2023 |
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01 May, 2023 |
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Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 |
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30 Apr, 2023 |
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Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022 |
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03 Jul, 2022 |
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Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 |
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15 Oct, 2021 |
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Cancer mortality not reduced by small vitamin D doses - Sept 2021 |
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21 Sep, 2021 |
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Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021 |
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17 Aug, 2021 |
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Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 |
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10 Jan, 2021 |
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Cancer patients in ICU with low vitamin D were 3.4 X more likely to die within a year – Dec 2020 |
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31 Dec, 2020 |
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Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 |
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09 Nov, 2020 |
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Cancer is leading cause of death - Vitamin D and Receptor activators help |
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09 Nov, 2019 |
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Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014 |
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08 Nov, 2019 |
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Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019 |
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10 Sep, 2019 |
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Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 |
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05 Jul, 2019 |
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People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 |
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05 Jul, 2019 |
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Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019 |
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07 May, 2019 |
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Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019 |
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13 Apr, 2019 |
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Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 |
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26 Nov, 2018 |
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Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival |
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10 Sep, 2018 |
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The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms – Jan 2018 |
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13 Jan, 2018 |
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Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 |
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29 Dec, 2017 |
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Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 |
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13 Jun, 2017 |
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Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 |
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15 Jun, 2016 |
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Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 |
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09 Nov, 2014 |
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Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 |
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30 Sep, 2014 |
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Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014 |
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17 Jun, 2014 |
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Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 |
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12 May, 2014 |
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More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 |
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08 May, 2014 |
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Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 |
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08 Apr, 2014 |
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Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 |
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06 Mar, 2014 |
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Vitamin D and Cancer Mortality – review Jan 2013 |
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17 Sep, 2013 |
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Mortality and Cancer varies with latitude in France too – 2010 |
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26 Oct, 2012 |
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More US deaths due to cancer than heart if dark skinned – Sept 2012 |
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18 Sep, 2012 |
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Lack of solar UVB in US is associated with some Cancers - 2006 |
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28 Dec, 2011 |
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Solar radiation, vitamin D and cancer incidence and mortality in Norway |
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13 Apr, 2010 |
20 Most-visited pages in Cancer (general) category
This list is automatically updated
Items found: 89
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Non-cancer colon growths 7 % less likely per 10 ng increase in Vitamin D – Oct 2011 |
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08 Dec, 2024 |
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Graphs of Vitamin D and Cancer – meta-analysis Dec 2011 |
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08 Dec, 2024 |
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Pancreatic cancer mortality 28% more likely if low vitamin D – meta-analysis Jan 2024 |
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28 Nov, 2024 |
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Analysis of 280 Breast Cancer meta-analyses: having low vitamin D was highly suggestive – umbrella July 2024 |
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28 Jul, 2024 |
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Bladder cancer in muscles 2.7 times more-likely if vitamin D less than 20 ng -meta-analysis May 2024 |
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23 May, 2024 |
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1.5X more likely to die of Prostate Cancer if low vitamin D when initially diagnosed – meta-analysis March 2024 |
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13 Mar, 2024 |
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Pancreatic Cancer survival 2.3 X more likely if good level of Vitamin D – meta-analysis Sept 2023 |
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15 Sep, 2023 |
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Thyroid Cancer 1.4 X higher risk if low vitamin D– meta-analysis Feb 2018 |
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29 Aug, 2023 |
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Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 |
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31 Jul, 2023 |
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16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023 |
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22 May, 2023 |
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Melanoma is 1.4X more-likely if low Vitamin D – meta-analysis May 2023 |
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18 May, 2023 |
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Breast Cancer not prevented by vitamin D when use small doses or for just a short time – Meta-analysis April 2023 |
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11 May, 2023 |
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Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 |
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30 Apr, 2023 |
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Breast Cancer risk - meta-analysis of 50 studies - Dec 2019 |
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25 Mar, 2023 |
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Ovarian Cancer 37 percent less likely if high vitamin D – meta-analysis March 2023 |
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20 Mar, 2023 |
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Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis Jan 2023 |
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08 Jan, 2023 |
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Melanoma might be suppressed by Vitamin D - many studies |
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25 Nov, 2022 |
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Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022 |
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13 Sep, 2022 |
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USPSTF says no evidence that Vitamins prevent CVD or Cancer (data disagrees) Aug 2022 |
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05 Sep, 2022 |
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Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022 |
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19 Aug, 2022 |
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Colorectal cancer 40 percent less likely if 1000 IU more Vitamin D – 21st meta-analysis – Oct 2021 |
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29 Oct, 2021 |
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Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis – June 2021 |
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02 Jul, 2021 |
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Lung Cancer death 40 percent less likely if high level of Vitamin D – meta-analysis Nov 2020 |
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24 Nov, 2020 |
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Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 |
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09 Nov, 2020 |
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Vitamin D fights 13 cancers – review of 35 meta-analyses – Oct 2020 |
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06 Oct, 2020 |
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Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020 |
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02 Oct, 2020 |
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Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020 |
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17 Sep, 2020 |
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3X less risk of Liver cancer if more than 30 ng of vitamin D – meta-analysis July 2020 |
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28 Jul, 2020 |
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Liver Cancer 8 percent less likely for every 4 ng higher level of vitamin D – Meta-analysis April 2020 |
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02 Apr, 2020 |
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Melanoma 2.1 X more likely if low vitamin D – meta-analysis Jan 2020 |
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11 Jan, 2020 |
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Breast Cancer risk reduced 17 percent by 1 hour of daily summer sun – meta-analysis Jan 2020 |
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07 Jan, 2020 |
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Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 |
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14 Dec, 2019 |
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Colon cancer both prevented and treated by Vitamin D – meta-analysis Dec 2019 |
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04 Dec, 2019 |
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Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 |
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09 Nov, 2019 |
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Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 |
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05 Jul, 2019 |
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People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 |
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05 Jul, 2019 |
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Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013 |
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16 Jun, 2019 |
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Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019 |
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13 Jun, 2019 |
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Variety of Vitamin D forms treat Prostate Cancer – RCT Review April 2019 |
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01 May, 2019 |
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Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis June 2017 |
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20 Mar, 2019 |
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Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019 |
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05 Mar, 2019 |
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16 percent less Prostate Cancer sometimes for each 10 ng vitamin D increase - meta-analysis Jan 2011 |
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13 Oct, 2018 |
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Lung Cancer risk decreased 2.4 percent with every 100 IU Vitamin D extra intake – meta-analysis Sept 2018 |
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15 Sep, 2018 |
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Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018 |
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18 Jul, 2018 |
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Thyroid Cancer 1.3X higher risk if low vitamin D (yet again) – meta-analysis June 2018 |
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02 Jun, 2018 |
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Cancer not treated by Vitamin D when ignore dose size, type, and length of trial – meta-analysis April 2018 |
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09 Apr, 2018 |
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Pancreatic cancer risk reduced 25 percent by just 10 micrograms of Vitamin D or Vitamin B12 – meta-analysis March 2018 |
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30 Mar, 2018 |
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Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018 |
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11 Jan, 2018 |
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Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 |
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29 Dec, 2017 |
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Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017 |
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14 Dec, 2017 |
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Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 |
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27 Jul, 2017 |
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Lymphoma, leukemia etc, survival poor if low vitamin D – meta-analysis March 2015 |
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06 Jul, 2017 |
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Lung Cancer less likely if vitamin D (higher level or supplement) – meta-analysis May 2015 |
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06 Jul, 2017 |
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Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 |
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13 Jun, 2017 |
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Lung Cancer risk decreases 5 percent for every 2.5 nanogram increase in Vitamin D – meta-analysis Sept 2015 |
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22 Feb, 2017 |
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Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016 |
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22 Dec, 2016 |
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Colorectal Cancer recurrence not prevented by 1,000 IU of vitamin D – meta-analysis Dec 2016 |
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09 Dec, 2016 |
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Bladder cancer modifiable risk factors include low vitamin D – meta-analysis March 2016 |
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08 Dec, 2016 |
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Bladder cancer 60 percent less likely if have high vitamin D – meta-analysis Dec 2015 |
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08 Dec, 2016 |
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Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 |
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12 Nov, 2016 |
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10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 |
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23 Sep, 2016 |
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Kidney cancer 22 percent less likely if high vitamin D – meta-analysis Nov 2015 |
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30 Mar, 2016 |
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Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis April 2015 |
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24 Dec, 2015 |
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Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis Oct 2014 |
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24 Dec, 2015 |
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Cancer risk weakly associated with vitamin D-binding protein – meta-analysis Sept 2015 |
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15 Oct, 2015 |
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Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis Aug 2015 |
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14 Aug, 2015 |
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Obesity causes 20 percent of all cancer, low vitamin D may be the connection – meta-analysis - Sept 2014 |
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31 May, 2015 |
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Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015 |
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03 May, 2015 |
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Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015 |
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11 Dec, 2014 |
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Breast Cancer – review of 2 RCT did not find association with 1000 IU of Vitamin D – July 2013 |
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16 Nov, 2014 |
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Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014 |
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30 Sep, 2014 |
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Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 |
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30 Sep, 2014 |
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Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 |
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12 May, 2014 |
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More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 |
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08 May, 2014 |
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Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 |
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08 Apr, 2014 |
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Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 |
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06 Mar, 2014 |
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Breast Cancer post menopause down 12 percent for every 5 ng of vitamin D – meta-analysis May 2013 |
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28 Oct, 2013 |
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Probably need more than 1000 IU of vitamin D to prevent cancer – meta-analysis Aug 2013 |
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20 Aug, 2013 |
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3.2 percent less Breast Cancer for 2.4 ng more vitamin D – meta-analysis June 2013 |
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08 Jul, 2013 |
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Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis Aug 2011 |
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10 Nov, 2012 |
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Breast cancer association with low vitamin D suggested by Meta-analysis -April 2010 |
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19 Jul, 2012 |
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Colon cancer probability increases with decreased vitamin D – Meta-analysis July 2011 |
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23 Jun, 2012 |
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Vitamin D has a complex relationship with Cancer – meta-analysis July 2011 |
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30 Sep, 2011 |
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Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010 |
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31 Aug, 2011 |
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Risk of Prostate Cancer weakly associated with vitamin D - meta-analysis March 2011 |
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11 Aug, 2011 |
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Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010 |
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17 Jan, 2011 |
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Meta-analysis not find low vitamin D years before breast cancer – Aug 2010 |
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10 Sep, 2010 |
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Meta-analysis confirmed that vitamin D and calcium prevents breast cancer – June 2010 |
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30 Aug, 2010 |
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Meta-analysis did not find strong association between vitamin D and breast cancer risk -April 2010 |
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12 May, 2010 |
See also web
- Phrases associated with cancer NYT Jan 2015
“failed tamoxifen”,“platinum resistant” or “refractory” patient, “relapsed” scans which are “clean,” “positive” or “advancing” spells trouble
nodes have been “harvested”; a tumor is “indolent, “minimal or acceptable side effects,” scanxiety,
Nothing about vitamin D
- How cancer cells form tumors by reaching out with ‘cables’ and grabbing cells Jan 2016 (nothing about vitamin D)
"Surprisingly, as little as five percent of cancerous cells are needed to form the tumors, a ratio previously unknown."
“It’s that these cells go out and actively recruit. It’s complicated stuff, and it’s not passive. No one had a clue that there were specialized cells in this process, and that it’s a small number that pulls all the rest in.”
Images from the movie
subset of the above?
VitaminDWiki - Vitamin D Receptor activation can be increased in many ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Metflormin (Kidney) Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the many VDR activators
| 541 |
studies in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
See also: | 49 |
studies in the Resveratrol category
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems
Health problems include: Autoimmune (| 19 |
studies), Breast Cancer (| 24 |
studies), Colon Cancer (| 14 |
studies), Cardiovascular (| 23 |
studies), Cognition (| 16 |
studies), Diabetes (| 25 |
studies), Hypertension (| 9 |
studies), Infant (| 22 |
studies), Lupus (| 6 |
studies), Metabolic Syndrome (| 4 |
studies), Mortality (| 4 |
studies), Multiple Sclerosis (| 16 |
studies), Obesity (| 17 |
studies), Pregnancy (| 25 |
studies), Rheumatoid Arthritis (| 11 |
studies), TB (| 8 |
studies), VIRUS (| 40 |
studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
| 541 |
studies in Vitamin D Receptor category
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
See also: | 49 |
studies in the Resveratrol category
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems
Health problems include: Autoimmune (| 19 |
studies), Breast Cancer (| 24 |
studies), Colon Cancer (| 14 |
studies), Cardiovascular (| 23 |
studies), Cognition (| 16 |
studies), Diabetes (| 25 |
studies), Hypertension (| 9 |
studies), Infant (| 22 |
studies), Lupus (| 6 |
studies), Metabolic Syndrome (| 4 |
studies), Mortality (| 4 |
studies), Multiple Sclerosis (| 16 |
studies), Obesity (| 17 |
studies), Pregnancy (| 25 |
studies), Rheumatoid Arthritis (| 11 |
studies), TB (| 8 |
studies), VIRUS (| 40 |
studies), Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
This page is in the following categories (# of items in each category)
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“One pill every two weeks fights diabetes, cancers, heart failure, and 21 other diseases.”
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