Vitamin D Receptor ( VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer
Nutrients. 2021 Jan 11;13(1):E200. doi: 10.3390/nu13010200.
Maria Latacz 1 2, Dominika Rozmus 1, Ewa Fiedorowicz 1, Jadwiga Snarska 3, Beata Jarmołowska 1, Natalia Kordulewska 1, Huub Savelkoul 4, Anna Cieślińska 1
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Vitamin D Receptor category with CANCER in the title (76 as of Feb 2022)
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Colorectal cancer (CRC) is one of the most commonly occurring neoplasias in humans. The prevalence of CRC rates is still rising. Although the exact background of the disease still remains unknown, it is believed that CRC may not only be a result of environmental factors, but also genetic ones. One of the mechanisms underlying CRC might be the vitamin D pathway, as CRC is the most closely linked neoplasia to vitamin D deficiency. This study shows a possible association of the vitamin D receptor (VDR) polymorphisms FokI, BsmI, ApaI, and TaqI with CRC susceptibility. A total of 103 patients diagnosed with CRC (61 men and 42 women, aged 57-82 years) and 109 healthy people (50 men and 59 women, aged 47-68 years) were genotyped using PCR-RFLP for FokI, BsmI, ApaI, and TaqI. None of the single nucleotide polymorphisms (SNPs) individually increased or decreased the risk of CRC.
The evaluation of haplotypes revealed two that might enhance the likelihood of CRC development:
- taB (OR = 30.22; 95% CI 2.81-325.31; p = 0.01) and
- tAb (OR = 3.84; 95% CI 1.29-11.38; p = 0.01).
In conclusion, genotyping is an easy and robust procedure that needs to be performed only once in a lifetime. A creation of a relevant SNP's panel might contribute to the identification of the groups that are at the greatest risk of CRC.