Table of contents
- Loading Dose overview
- TOP articles in Loading Dose of Vitamin D
212 Loading Dose articles - VitaminDWiki -
6 Meta-analyses of Loading Dose - Loading dose assocations with other VitaminDWiki categories
Loading Dose overview
212 items in category
see also Overview Loading of vitamin D Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has68 items
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading dosesTOP articles in Loading Dose of Vitamin D
- Surgery complications cut in half by 300,000 IU of vitamin D 2 weeks before (hip and knee) – RCT May 2024
- ICU patients typically benefit from 300-500,000 IU of Vitamin D - many studies
- Single 600,000 IU dose of nanoemulsion Vitamin D is safe and effective to fight COVID, even if delay until enter ICU – RCT May 2024
- Vitamin D loading dose of 30,000 IU twice a week is safe and effective – RCT July 2023
- Large dose Vitamin D before surgery was found to help by 35 studies
- Vitamin D is needed before many surgeries – many studies and RCTs
- 400,000 IU of vitamin D 3 days after COVID symptoms reduced 14 day mortality by 3X – Annweiler RCT May 2022
- High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022
- Take lots of Vitamin D at first signs of COVID
- Rapid Vitamin D Delivery May Result in Better COVID Outcomes - Dec 9, 2021
- Vitamin D loading doses quickly and safely raise levels – meta-analysis Dec 2021
- Childhood cancers – give Vitamin D loading dose if low – Oct 2021
- French recommended 200,000 IU of Vitamin D to stop COVID-19 - Jan 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- Vitamin D loading dose (stoss therapy) proven to improve health
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018
- Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT Nov 2018
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Reasons for Low Vitamin D and what to do
- Healthy in Seven Days - Loading dose of Vitamin D – book 2014
- Can get 50,000 IU Vitamin D anywhere on the globe
212 Loading Dose articles - wiki page:
- Major Depressive Disorder RCTs often use Vitamin D: 50,000 IU weekly or single 300,000 IU - Review May 2025
- Vitamin D before surgery helped again (Thyroid in this case) - meta-analysis April 2025
- ICU patients 6X more likely to die if poor response to 570,000 IU of Vitamin D – RCT April 2025
- Vitamin D meets Hill’s Criteria for fighting COVID (adult about 5,000 IU daily) – Feb 2025
- Vitamin D loading doses typically helped critically ill, but never harmed (21 RCTs) - Jan 2025
- Loading dose of 60,000 IU Vitamin D once a week for 5 weeks safely raised deficient to above 30 ng – Nov 2024
- Surgery complications cut in half by 300,000 IU of vitamin D 2 weeks before (hip and knee) – RCT May 2024
- Less ultramarathon heart damage if take 150,000 IU of Vitamin D a day earlier – RCT July 2024
- Growing pains reduced in 91% of children with a single dose of Vitamin D – July 2024
- ICU patients typically benefit from 300-500,000 IU of Vitamin D - many studies
- Single 600,000 IU dose of nanoemulsion Vitamin D is safe and effective to fight COVID, even if delay until enter ICU – RCT May 2024
- 40 cents of Vitamin D given once during pregnancy reduced respiratory problems by 3% – May 2023
- Large Vitamin D loading doses recomended (Italy, goal 40-60 ng) - 2011
- Vitamin D loading dose of 30,000 IU twice a week is safe and effective – RCT July 2023
- Breastfeeding Vitamin D loading dose of 300,000 IU is OK - UK govt. Dec 2023
- Vitamin D 100,000 IU loading dose and stem cell transplants – RCT Oct 2023
- Pain relieved by Vitamin D if trial lasted more than 5 months (endometriosis, 50K weekly for 12 months) – Aug 2023
- Randomized Controlled Trials in VitaminDWiki - many studies
- Large dose Vitamin D before surgery was found to help by 35 studies
- NAFLD and Vitamin D - many studies
- COVID recovery 1.6X faster after 200,000 IU of Vitamin D RCT – Feb 2023
- Vitamin D is needed before many surgeries – many studies and RCTs
- Inflammatory markers reduced by single 80,000 IU of vitamin D (Saudi) – Sept 2022
- Treat COVID with early high-dose Vitamin D (20th as of June 2022)
- 400,000 IU of vitamin D 3 days after COVID symptoms reduced 14 day mortality by 3X – Annweiler RCT May 2022
- COVID patients not helped by 500K IU of Vitamin D (they already had enough) – May 2022
- Loading dose of Vitamin D for patients hospitalized with COVID (140,000 IU) – RCT completed 2021
- COVID Ventilation 2X less likely if 200,000 IU of Vitamin D when enter hospital – May 2022
- Half as much AFIB after bypass if 600,000 IU of vitamin D before surgery – RCT April 2022
- High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022
- In vitro fertilization NOT helped by 600,000 IU of vitamin D – RCT Sept 2021
- FLCCC COVID guidelines now include vitamin D loading doses - Jan 2022
- Take lots of Vitamin D at first signs of COVID
- Rapid Vitamin D Delivery May Result in Better COVID Outcomes - Dec 9, 2021
- Vitamin D loading doses quickly and safely raise levels – meta-analysis Dec 2021
- Childhood cancers – give Vitamin D loading dose if low – Oct 2021
- French recommended 200,000 IU of Vitamin D to stop COVID-19 - Jan 2021
- COVID-19 mortality reduced 4X (chart looks like 2X) by large, infrequent doses of Vitamin D in France – July 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- Single 200,000 IU of vitamin D did not benefit the obese in various ways (not a surprise) – RCT Feb 2021
- 600,000 IU of Vitamin D helped 26 out of 28 COVID-19 patients in ICU (Brazil and Bolivia) June 2021
- ICU mortality reduced by non-oral vitamin D – meta-analysis May 2021
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- Infectious Mononucleosis (virus) and Vitamin D - many studies
- Temporary hair loss (Telogen Effluvium) treated by Vitamin D (200,000 IU, twice a month) - March 2021
- Taking Vitamin D just before and after surgery helps (open-heart in this case) – RCT Feb 2021
- Half as many problems if take Vitamin D (300,000 IU) before thyroidectomy – RCT Jan 2021
- Fewer days in hospital if 300,000 IU of vitamin D before brain surgery - RCT Feb 2021
- ICU Vitamin D injection (300,000 IU) helped - RCT Feb 2021
- Those getting an injection of 300,000 IU Vitamin D got out of the ICU a week sooner – RCT Dec 2020
- Those getting high dose vitamin D were 7 X less likely to die of COVID-19 - Dec 11, 2020
- COVID-19 Vitamin D Overview - Sunil video and transcript - Dec 8, 2020
- Vitamin D has eliminated ICU COVID-19 in hospital in Dubai since June - Sept 26, 2020
- Severe COVID-19 not fought by vitamin D when given too late - RCT Nov 18, 2020
- COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020
- 44 percent of successful RCTs in VitaminDWiki used non-daily dosing - Nov 2020
- French National Academy recommended 100,000 IU of Vitamin D to elderly to fight COVID-19 - May 2020
- Residents of a Nursing Home who choose monthly Vitamin D had 4X fewer COVID-19 deaths – Nov 2, 2020
- ICU patients greatly helped by Vitamin D loading doses – if gut-friendly – Oct 2020
- Fewer days in ICU after 300,000 IU of vitamin D, but not 540,000 – meta-analysis Aug 2020
- Vitamin D reduced depression – single 300,000 IU – RCT Aug 2020
- Vitamin D during pregnancy – single 200,000 IU similar to daily 5,000 IU – April 2020
- Vitamin D loading dose (stoss therapy) proven to improve health
- 3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020
- Child soccer players who were deficient were helped by a single 200,000 IU vitamin D dose – RCT May 2020
- 100,000 IU daily of Vitamin D for 5 days increased Hemoglobin in Mechanically Ventilated adults – RCT Jan 2018
- Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020
- Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020
- Elderly Vitamin D Loading Dose of 500,000 IU is safe and effective – RCT 2009
- Hip surgery with multiple doses of 50,000 IU of vitamin D weekly both before and after – RCT 2023
- Use of Vitamin D in a trauma surgery - Dr. Matthews on Facebook – Jan 2020
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Infant Vitamin D doubles 6 months after birth (can double in 2 weeks)– Oct 2019
- Vitamin D levels in children optimized with six Vitamin D biscuits – RCT Nov 2018
- Surgeries often deplete Vitamin D - 300,000 IU resulted in little response – Nov 2018
- 10 fewer days of ICU Mechanical Ventilation 300,000 IU injection of vitamin D – RCT March 2019
- Ulcerative Colitis significantly reduced by 480,000 IU loading dose of nano Vitamin D – RCT July 2019
- 2X improved development by severely malnourished children with 2 loading doses of vitamin D – RCT May 2018
- Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- 100,000 IU Vitamin D weekly for 4 weeks is safe and effective for children – May 2019
- Treating Vitamin D deficiency in senior women – such as 50,000 IU daily for 15 days then twice a month – Review April 2019
- ICU adults getting 540,000 IU of Vitamin D were 2X more likely to be alive 30 days later – RCT June 2019
- Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D – March 2019
- Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018
- Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT Nov 2018
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Reasons for Low Vitamin D and what to do
- Cerebral malaria deaths prevented by loading dose of vitamin D (mice) – Sept 2018
- Esophageal Cancer surgery helped by 300,000 IU of Vitamin D – RCT Sept 2018
- Vitamin D loading dose of 300,000 IU for children – 3 weeks with capsules, biscuits, injection – RCT Aug 2018
- Vitamin D could be restored in 60 days (actually much faster) – June 2018
- Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
- Restore Vitamin D levels with 200,000–400,000 IU over 2 months, followed by on-going – March 2018
- Far more Vitamin D in breast milk from a 150,000 IU dose than from daily 5,000 IU – RCT May 2018
- Neuropathy - 5X more had a good Quality of Life after 600,000 IU of Vitamin D - 2017
- Weekly dosing of vitamin D is far better than single large dose (chronic liver, children) – March 2018
- Biochemical rickets non-existent if breastfeeding mother got 600,000 IU of vitamin D (3 dollars) – RCT Dec 2017
- Vitamin D injection helped migrants a bit, but some had poor or even negative responses – Dec 2017
- 600,000 IU of vitamin D – 42 ng at 3 months for 1 inj, 3 inj, oral monthly, oral weekly - Oct 2017
- Spinal Cord injury outcome was better if got Vitamin D and progesterone within 4 hours – RCT 2016
- Just 2 doses of Vitamin D resulted in many benefits (Chronic Kidney Disease)– Jan 2018
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Vitamin D injection of 600,000 IU (response by 10 individuals)– Sept 2017
- Birth rates doubled with Vitamin D - 300,000 IU for infertile men – RCT Nov 2017
- Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023
- Critically ill children – randomized clinical trial to give single doses of up to 400,000 IU of vitamin D – 2019
- Vitamin D Deficiency Flowchart for UK Primary Care - August 2017
- Early Rheumatoid Arthritis helped by 300,000 IU of vitamin D – RCT June 2017
- Rheumatoid Arthritis nicely treated by Vitamin D (300,000 IU loading dose) – May 2017
- Canadian grant funding lost for prescribing 50,000 IU of vitamin D – July 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Vitamin D loading doses reduce ICU mortality by 30 percent – meta-analysis April 2017
- Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT July 2016
- Vitamin D – individual responses to 100,000 IU – March 2017
- Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017
- Quick restoration of vitamin D in children – 10,000 IU per kg loading dose was not enough – Jan 2017
- Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
- 80,000 IU monthly winter vitamin D got all healthy people above 20 ng (need more) – Feb 2017
- 300,000 IU loading dose of vitamin D does not help the obese much – Jan 2017
- Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016
- Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017
- Takes a year to restore children and youths to good levels of vitamin D without loading dose - RCT Dec 2016
- Pneumonia in children not stopped for 6 months by single dose of vitamin D (3 months max) – RCT Nov 2016
- Loading dose greatly improves subsequent daily Vitamin D if have liver fibrosis – RCT Nov 2016
- Single 300,000 IU Vitamin D dose lasts about 2 months– Nov 2016
- Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016
- Children in Intensive Care need Vitamin D loading dose of 10000 IU per kg (nearing a consensus) - Oct 2016
- Vitamin D Loading dose - 20,000 IU daily is not enough if obese, etc. (Cancer) great table and chart – Oct 2016
- Newborn Vitamin D - single 50,000 IU is better than daily – RCT Sept 2016
- Wisdom tooth (3rd molar) extraction helped by Vitamin D loading dose – RCT March 2016
- Pediatric trials of high dose vitamin D -163 are in a single online database – Feb 2016
- Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D – Feb 2016
- Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT Jan 2016
- PMS reduced by half in girls who had low levels of vitamin D – RCT Dec 2015
- Rapid Normalization of Vitamin D in Critically Ill Children (10,000 IU per kg) – clinical trial
- Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months – Oct 2015
- 600,000 vitamin D loading doses – good response to both oral and muscular – Oct 2015
- Large dose of vitamin D (200,000 IU) lasts for less than 90 days – Feb 2015
- Bio-available Vitamin D following mega-doses (up to 500,000 IU) – Clinical trial due 2018
- Common cause of dizziness (BPPV) reduced 5 X by several doses of 50,000 IU of vitamin D – 2015, 2016
- 200,000 IU restored levels in HIV children having low vitamin D - Nov 2014
- Vitamin D average level was 33 ng after 400,000 IU in 2 months - RCT July 2015
- Single dose (up to 60,000 IU) vitamin D raised levels in 87 percent of Cystic fibrosis patients – RCT March 2013
- 500,000 IU of vitamin D cut in half the hospital days following a lung failure – RCT 2015
- 5 days of 100,000 IU of Vitamin D increased hemoglobin in critical illness – RCT April 2015
- VITdAL-ICU - AMA RCT Sept 2014
- Clinical trials using a LOT of vitamin D intervention – Jan 2015
- Vitamin D loading doses of up to 400,000 IU OK for adolescents – meta-analysis Dec 2014
- Vitamin D restored in teens by doses totalling 300,000 IU – Nov 2014
- Critically ill need vitamin D – how much and which test to use is TBD – Nov 2014
- Will vitamin D loading dose and 50,000 IU monthly will help after melanoma surgery – Oct 2014
- ICU survival increased with vitamin D single 540K IU loading dose - JAMA Sept 2014
- Osteoporosis Society UK: 20 ng vitamin D is sufficient, loading dose 300,000 IU – Sept 2014
- Vitamin D levels of seniors restored with 50,000 IU weekly for 8 weeks – April 2014
- Vitamin D supplementation protocols: loading, injection, etc – RCT June 2014
- Long time between large vitamin D injections resulted in 6X increase in health complaints – April 2014
- Sickle cell Vitamin D deficiency corrected with 160 K IU loading dose – July 2014
- Normalize vitamin D safely within 1-2 weeks – June 2014
- Loading dose of 300,000 IU of vitamin D does not last long – March 2014
- Neonate loading dose of 30,000 IU vitamin D helped a lot – May 2014
- Healthy in Seven Days - Loading dose of Vitamin D – book 2014
- Can get 50,000 IU Vitamin D anywhere on the globe
- Diabetes (Type II) reduced by single injection of 300,000 IU of vitamin D3 – RCT March 2014
- Vitamin D for Italians – Senior 2300 IU, if deficient loading dose of at least 300,000 IU– Med Society 2011
- 400,000 IU of vitamin D reduced adult pain and improved quality of life – March 2014
- Loading Dose of Vitamin D
- Injection of 300,000 IU of vitamin D3 similar to 10 months of oral 25,000 IU – Jan 2014
- Large single dose of more than 300,000 IU of vitamin D works well for 3 months – Review Nov 2013
- 372 types of vitamin D prescriptions in France, 200,000 IU was the most popular – Oct 2013
- Review of Vitamin D (including free, frequency, injection, how much.) – Sept 2013
- Vitamin D injections of a total of 1,800,000 IU reduced shinbone tenderness – Feb 2013
- Loading dose for Vitamin D
- Guideline following hip fracture – 50000 IU vitamin D daily for 7 days – Jan 2013
- Rickets cured for 3 months with 10,000 IU per kg vitamin D (600,000 IU max) – Sept 2012
- Lupus flares totally eliminated by loading dose then 100000 IU of vitamin D each month – Oct 2012
- Vitamin D deficiency somewhat treated with weekly 50000 IU Vitamin D2 – Sept 2012
- Recurrence of child pneumonia delayed by 100000 IU of vitamin D – RCT Oct 2010
- 600,000 IU vitamin D normalized virtually all seniors in 3 months (Injection better than oral)– May 2012
- Huge gap between vitamin D advice and actual prescriptions – April 2012
- 600,000 IU of vitamin D2 every 4 months for decades in East Germany – 1987
- 300,000 IU every 3 months helped raise vitamin D levels in half of RA patients – April 2012
- Vitamin D Replentishment (Loading doses are not toxic)– Feb 2012
- 100,000 IU single dose of vitamin D - 2010
- Loading dose of 300,000 IU vitamin D every 6 months – Dec 2011
- France attempts to restock vitamin D levels with 7000 or 14000 IU daily – Nov 2011
- 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011
- Vitamin D2 loading doses did not increase, and may have decreased blood levels– June 2011
- Variety of vitamin D loading dose recommendations in the UK - 2011
- Half of the seniors needed more than 1700 IU vitamin D3 (50000 monthly) – April 2011
- 300,000 IU vitamin D helped seniors in many ways – May 2011
- 300000 IU vitamin D monthly may treat MS – May 2011
- 540000 IU before ICU raised vitamin D by 25 ng in 2 days – March 2011
- 300000 IU injection of vitamin D3 – Mar 2010
- Critical reappraisal of vitamin D deficiency – 800 IU and some megadose Jan 2010
- Can You Overdose on Vitamin D - It's Harder Than You Think
- 600000 IU dose raised youth vitamin D level by 60 ng in 3 days – July 2010
- 300000 IU of vitamin D every 3 months may not have been enough – July 2010
- Vitamin D and UV safe and toxic doses - Vieth 1999
- Vitamin D3 loading dose of 500,000 IU for elderly – Aug 2009
- Barefoot on mega doses of vitamin D and his book on Cancer
- Grade A recommendations for vitamin D - May 2009
- Hip surgery followed by 100000 IU then 1000 IU of vitamin D daily – June 2010
- Overview Loading of vitamin D
- 600,000 IU intramuscular D3 helped BMD after pancreatic surgery – June 2010
- Megadose injection of up to 600,000 IU vitamin D3 every three months for adolescents - April 2010
VitaminDWiki -
6 Meta-analyses of Loading Dose This list is automatically updated
- High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022
- Vitamin D loading doses quickly and safely raise levels – meta-analysis Dec 2021
- ICU mortality reduced by non-oral vitamin D – meta-analysis May 2021
- Fewer days in ICU after 300,000 IU of vitamin D, but not 540,000 – meta-analysis Aug 2020
- Vitamin D loading doses reduce ICU mortality by 30 percent – meta-analysis April 2017
- Vitamin D loading doses of up to 400,000 IU OK for adolescents – meta-analysis Dec 2014
Loading dose assocations with other VitaminDWiki categories
Summary of Associations
Associated category Associations Results
41 pages in both categories: Loading dose for Vitamin D + Trauma and surgery
4 pages in both categories: Loading dose for Vitamin D + Cost savings with Vitamin D
29 pages in both categories: Loading dose for Vitamin D + Injection
23 pages in both categories: Loading dose for Vitamin D + Infant-Child
49 pages in both categories: Loading dose for Vitamin D + Intervention
4 pages in both categories: Loading dose for Vitamin D + Rheumatoid Arthritis
6 pages in both categories: Loading dose for Vitamin D + Pregnancy
8 pages in both categories: Loading dose for Vitamin D + Diabetes
4 pages in both categories: Loading dose for Vitamin D + Obesity
9 pages in both categories: Loading dose for Vitamin D + Seniors
4 pages in both categories: Loading dose for Vitamin D + Vitamin D3 instead of D2
4 pages in both categories: Loading dose for Vitamin D + Overview for doctors
7 pages in both categories: Loading dose for Vitamin D + Vitamin D in Europe
8 pages in both categories: Loading dose for Vitamin D + Pain - chronic
6 pages in both categories: Loading dose for Vitamin D + Breathing
24 pages in both categories: Loading dose for Vitamin D + Top news
23 pages in both categories: Loading dose for Vitamin D + Virus
19 pages in both categories: Loading dose for Vitamin D + Intervention - non daily
4 pages in both categories: Loading dose for Vitamin D + Better than daily
6 pages in both categories: Loading dose for Vitamin D + Youth
5 pages in both categories: Loading dose for Vitamin D + Toxicity of Vitamin D
4 pages in both categories: Loading dose for Vitamin D + Rickets
7 pages in both categories: Loading dose for Vitamin D + High-Dose
4 pages in both categories: Loading dose for Vitamin D + Deficiency of Vitamin D
6 pages in both categories: Loading dose for Vitamin D + Meta-analysis of Vitamin D
9 pages in both categories: Loading dose for Vitamin D + How much Vitamin D
Loading Dose of Vitamin DPrinter Friendly Follow this page for updates33843 visitors, last modified 23 Dec, 2023, This page is in the following categories (# of items in each category)- VitaminDWiki -