Vitamin D Receptor activation in cells varies by 100 X - Carlberg April 2023

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Vitamin D: A master example of nutrigenomics

Redox Biology 62 (2023) 102695 https://doi.org/10.10167j.redox.2023.102695
Carsten Carlberg a,b’ c.carlberg at pan.olsztyn.pl , Marianna Raczyk a, Natalia Zawrotna a
a Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, PL-10748, Olsztyn, Poland
b School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211, Kuopio, Finland

Vitamin D target genes Epigenome Transcriptome Immune system Personalized nutrition
Nutrigenomics attempts to characterize and integrate the relation between dietary molecules and gene expres­sion on a genome-wide level. One of the biologically active nutritional compounds is vitamin D3, which activates via its metabolite 1a,25-dihydroxyvitamin D3 (1,25(OH)2D3) the nuclear receptor VDR (vitamin D receptor). Vitamin D3 can be synthesized endogenously in our skin, but since we spend long times indoors and often live at higher latitudes where for many winter months UV-B radiation is too low, it became a true vitamin. The ligand- inducible transcription factor VDR is expressed in the majority of human tissues and cell types, where it mod­ulates the epigenome at thousands of genomic sites. In a tissue-specific fashion this results in the up- and downregulation of primary vitamin D target genes, some of which are involved in attenuating oxidative stress. Vitamin D affects a wide range of physiological functions including the control of metabolism, bone formation and immunity. In this review, we will discuss how the epigenome- and transcriptome-wide effects of 1,25 (OH)2D3 and its receptor VDR serve as a master example in nutrigenomics. In this context, we will outline the basis of a mechanistic understanding for personalized nutrition with vitamin D3.
 Download the PDF from VitaminDWiki

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4+ VitaminDWiki pages have CARLBERG in the title

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21 Carlberg publications 2021 - Feb 2024

1. Vitamin D and Aging: Central Role of Immunocompetence
2. Nutrigenomics and redox regulation: Concepts relating to the Special Issue on nutrigenomics.
3. Linking Mechanisms of Vitamin D Signaling with Multiple Sclerosis.
4. In Vivo Regulation of Signal Transduction Pathways by Vitamin D Stabilizes Homeostasis of Human Immune Cells and Counteracts Molecular Stress.
5. Intervention Approaches in Studying the Response to Vitamin D3 Supplementation.
6. Genomic signaling of vitamin D.
7. Vitamin D: A master example of nutrigenomics.
8. Nutrigenomics in the context of evolution.
9. Guidelines for Preventing and Treating Vitamin D Deficiency: A 2023 Update in Poland.
10. A Pleiotropic Nuclear Hormone Labelled Hundred Years Ago Vitamin D.
11. A Single Oral Vitamin D3 Bolus Reduces Inflammatory Markers in Healthy Saudi Males.
12. A Single Vitamin D3 Bolus Supplementation Improves Vitamin D Status and Reduces Proinflammatory Cytokines in Healthy Females.
13. Vitamin D in the Context of Evolution.
14. Gene-Regulatory Potential of 25-Hydroxyvitamin D3 and D2.
15. Vitamin D and Its Target Genes.
16. Time-Resolved Gene Expression Analysis Monitors the Regulation of Inflammatory Mediators and Attenuation of Adaptive Immune Response by Vitamin D.
17. Vitamin D and Pigmented Skin.
18. Transcriptome-Wide Profile of 25-Hydroxyvitamin D3 in Primary Immune Cells from Human Peripheral Blood.
19. Replacing Saturated Fat with Polyunsaturated Fat Modulates Peripheral Blood Mononuclear Cell Gene Expression and Pathways Related to Cardiovascular Disease Risk Using a Whole Transcriptome Approach.
20. Vitamin D and the risk for cancer: A molecular analysis.
21. A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes.

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VitaminDWiki – Vitamin D Receptor is associated in over 58 autoimmune studies

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VitaminDWiki – Cancer increases if poor Vitamin D Receptor

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

• Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
• Cancer and the Vitamin D Receptor, a primer – Sept 2017
• Vitamin D Receptor (Cancers OR Viruses) - many studies
• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
• Cancer (general) and VDR 23 articles
• Breast Cancer and VDR 24 articles
• Colon Cancer and VDR 14 articles
• Prostate Cancer and VDR 7 articles
• Skin Cancer and VDR 10 articles
  • Note some Health problems, such as some Cancers, protect themselves
    by actively reducing Receptor activation

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39+ VitaminDWiki Mortality pages have CANCER in the title

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20 Most-visited pages in Cancer (general) category

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89+ Cancer Meta-analyses in VitaminDWiki

This list is automatically updated

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See also web

• Phrases associated with cancer NYT Jan 2015
  “failed tamoxifen”,“platinum resistant” or “refractory” patient, “relapsed” scans which are “clean,” “positive” or “advancing” spells trouble
  nodes have been “harvested”; a tumor is “indolent, “minimal or acceptable side effects,” scanxiety,
  Nothing about vitamin D
• How cancer cells form tumors by reaching out with ‘cables’ and grabbing cells Jan 2016 (nothing about vitamin D)
  "Surprisingly, as little as five percent of cancerous cells are needed to form the tumors, a ratio previously unknown."
  “It’s that these cells go out and actively recruit. It’s complicated stuff, and it’s not passive. No one had a clue that there were specialized cells in this process, and that it’s a small number that pulls all the rest in.”
  Images from the movie

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VitaminDWiki - The risk of 50+ diseases at least double with poor Vitamin D Receptor

VitaminDWiki - Vitamin D Receptor activation can be increased in many ways

Resveratrol,  Omega-3,   Magnesium,  Zinc,   Quercetin,   non-daily Vit D,   Curcumin,   Berberine,  intense exercise, Butyrate   Sulforaphane  Metflormin (Kidney)   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the many VDR activators

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VitaminDWiki – Resveratrol improves health (Vitamin D receptor, etc.) - many studies contains

• The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
• Resveratrol is one of 14+ ways to negate the Vitamin D Receptor restrictions
• Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi
• Benefits of Resveratrol, like Vitamin D, appear to be increased when used with other things
  • Quercetin and Curcumin in the case of Resveratrol

20 articles in both of the categories Resveratrol and Vitamin D Receptor