Inflammation associated with Cancer reduced by Vitamin D – meta-analysis May 2023

Effects of vitamin D supplementation on inflammatory response in patients with cancer and precancerous lesions: Systematic review and meta-analysis of randomized trials

Clin Nutr. 2023 May 17;S0261-5614(23)00151-6. doi: 10.1016/j.clnu.2023.05.009
Tafirenyika Gwenzi 1, Anna Zhu 2, Petra Schrotz-King 3, Ben Schöttker 4, Michael Hoffmeister 5, Hermann Brenner 6

Background & aims: Inflammation plays a key role in tumor development and progression. Vitamin D has potential tumor suppressing effects through modulation of inflammatory processes. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to summarize and evaluate the effects of vitamin D3 supplementation (VID3S) on serum inflammatory biomarkers among patients with cancer or pre-cancerous lesions.

Methods: We searched PubMed, Web of Science and Cochrane databases until November 2022. The effects of VID3S were estimated from pooled standardized mean differences (SMDs) with their 95% confidence intervals (CIs) for inflammatory biomarker follow-up levels between intervention and control groups.

Results: Meta-analysis of eight RCTs (total of 592 patients with cancer or pre-cancerous conditions) showed that VID3S significantly lowered levels of serum tumor necrosis factor (TNF)-α (SMD [95%CI]: -1.65 [-3.07; -0.24]). VID3S also resulted in statistically non-significantly lower serum levels of interleukin (IL)-6 (SMD [95%CI]: -0.83, [-1.78; 0.13]) and C-reactive protein (CRP) (SMD [95%CI]: -0.09, [-0.35; 0.16]), whereas IL-10 levels were unaltered (SMD [95%CI]: -0.00, [-0.50; 0.49]).

Conclusion: Our study shows evidence of a significant reduction of TNF-α levels by VID3S for patients with cancer or precancerous lesions. Patients with cancer or precancerous lesions may benefit from personalized VID3S in suppressing tumour-promoting inflammatory response.

Prospero registration number: CRD42022295694.
No such attachment on this page

Note: Many of the trials used too little vitamin D to be of any possible benefit

4+ VitaminDWiki Inflammation pages with CANCER in the title

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VitaminDWiki – Cancer category contains

• Cancer 304 items Overview Cancer and vitamin D
• Cancer and Vitamin D - many studies
• After Cancer Diagnosis 117 items
• Bladder Cancer 28 items
• Breast Cancer 263 items Overview Breast Cancer and Vitamin D
• Colon Cancer 147 items Overview Cancer-Colon and vitamin D
• Leukemia 19 items
• Liver Cancer 17 items
• Lung Cancer 56 items Overview Lung cancer and vitamin D
• Lymphoma Cancer 26 items
• Other Cancer 69 items
• Ovarian Cancer 26 items
• Pancreatic Cancer 59 items
• Prostate Cancer 106 items Overview Prostate Cancer and Vitamin D
• Skin Cancer 121 items Overview Suntan, melanoma and vitamin D
• Childhood Cancers - Vitamin D can help - many studies
• Easiest way to treat cancer – take Vitamin D – Nov 2022
• 13 Cancers are helped by Vitamin D – Biobank July 2023
• 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
• Vitamin D prevents and treats cancer in many ways – May 2021
• Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
• Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
• Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
• 8 ways that Cancer might be prevented by Vitamin D - June 2019
• Cancer stem cells and Vitamin D - many studies
• Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
• Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
• Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
• Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
• Melanoma 25 X more likely if low vitamin D – Feb 2018
• Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018

VitaminDWiki – Cancer increases if poor Vitamin D Receptor (not mentioned in study on this page)

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

• Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
• Cancer and the Vitamin D Receptor, a primer – Sept 2017
• Vitamin D Receptor (Cancers OR Viruses) - many studies
• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
• Cancer (general) and VDR 23 articles
• Breast Cancer and VDR 24 articles
• Colon Cancer and VDR 14 articles
• Prostate Cancer and VDR 7 articles
• Skin Cancer and VDR 10 articles
  • Note some Health problems, such as some Cancers, protect themselves
    by actively reducing Receptor activation

39+ VitaminDWiki Mortality pages have CANCER in the title

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20 Most-visited pages in Cancer (general) category

89+ Cancer Meta-analyses in VitaminDWiki

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See also web

• Phrases associated with cancer NYT Jan 2015
  “failed tamoxifen”,“platinum resistant” or “refractory” patient, “relapsed” scans which are “clean,” “positive” or “advancing” spells trouble
  nodes have been “harvested”; a tumor is “indolent, “minimal or acceptable side effects,” scanxiety,
  Nothing about vitamin D
• How cancer cells form tumors by reaching out with ‘cables’ and grabbing cells Jan 2016 (nothing about vitamin D)
  "Surprisingly, as little as five percent of cancerous cells are needed to form the tumors, a ratio previously unknown."
  “It’s that these cells go out and actively recruit. It’s complicated stuff, and it’s not passive. No one had a clue that there were specialized cells in this process, and that it’s a small number that pulls all the rest in.”
  Images from the movie