Bone 126 (2019) 59-77
The study appears to ignore many of the genes which reduce the amount of Vitamin D in the blood which gets to the tissues
CYP27B1 category listing contains the following
The CYP27B1 gene activates Vitamin D in the Kidney, Skin, Lungs, Brain, Eyes Breasts etc.
Poor CYP27B1 is assocated with COVID, Miscarriage, Lupus, Alz, Parkinson, MSA, Rickets
CYtochrome P450 family 27 subfamily B member 1 = 25-Hydroxyvitamin D3 1-alpha-hydroxylase
66 items in CYP27B1 category 348 articles in the Genetics 544 articles in Vitamin D Receptor 180 articles in Vitamin D Binding Protein - CYP27B1 and other genes are less activated in seniors
- CYP27B causes many health problems – March 2020
- Every Parkinson’s brain had a poor CYP27B1 gene
What can be done if have a poor CYP27B1
- Larger doses of Vitamin D
- More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
- Additional sources: UV
- Increase Vitamin D metabolism: additional Magnesium, Omega-3
- All cytochrome P450 enzymes require Mg++ as a cofactor
- Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR
Vitamin D blood test misses CYP27B1 and other genes
Additional information on the Genes in VitaminDWiki
Gene # of pages Location CYP27A1 449 (Sept 2019) Liver *CYP2R1 826 (Sept 2019) Liver & Tissue CYP27B1 1430 (Sept 2019) Kidney & Tissue CYP24A1 28 in title - May 2022] excrete excess - Vitamins regulate some human genes – Feb 2020
- The genetics of vitamin D – Oct 2018
- Does survival of the less fit mean less health (poor genes may be inherited)
- genes getting worse over generations
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019
Vitamin D Receptor is associated in over 58 autoimmune studies
Vitamin D Receptor and Cancers
89+ Vitamin D Receptor pages with CANCER in the title
This list is automatically updatedNo results for query.
Vitamin D Binding Protein category listing has
180 items is mentioned in the study Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D
Vitamin D Binding Protein has a list of health problemsIncreased
RiskHealth Problem 11 X Preeclampsia 6.5X T1D in SA Blacks 6 X Food Allergy 5 X PTSD 4 X, 5X Kidney Cancer 4 X Poor Response to Oral Vitamin D 3 X Ear infection 2.8 X MS 2.5 X Severe Autism 2 X Colorectal Cancer 2 X Prostate Cancer -in those with dark skins 1.3 X Infertility Download the PDF fromSci-Hub VitaminDWiki
Heritability
Xia Jianga,b’*, Douglas P. Kiel' -'1-6, Peter Kraft3
a Program in Genetic Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Brookline, Boston 02115, USA
b Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Nobels vagen 13, Stockholm 17177, Sweden
c Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, United States
d Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, United States
e Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA 02142, United StatesVitamin D plays an essential role in human health as it influences immune function, cell proliferation, differentiation and apoptosis. Vitamin D deficiency has been associated with numerous health outcomes, including bone disease, cancer, autoimmune disease, cardiovascular conditions and more. However, the causal role of vitamin D beyond its importance for bone health remains unclear and is under much debate.
Twin and familial studies from past decades have demonstrated a nontrivial heritability of circulating vitamin D concentrations.
Several large-scale genome-wide association studies (GWAS) have discovered associations of GC, NADSYN1/ DHCR7, CYP2R1, CYP24A1, SEC23A, AMDHD1 with serum levels of vitamin D. A recent whole genome sequencing (WGS) study, combined with deep imputation of genome-wide genotyping, has identified a low-frequency synonymous coding variant at CYP2R1. Information on these genetic variants can be used as tools for downstream analysis such as Mendelian randomization. Here, we review the genetic determinants of circulating vitamin D levels by focusing on new findings from GWAS and WGS, as well as results from Mendelian randomization analyses conducted so far for vitamin D with various traits and diseases. The amount of variation in vitamin D explained by genetics is still small, and the putative causal relationship between vitamin D and other diseases remains to be demonstrated.The genetics of vitamin D – Oct 2018(Cached) Printer Friendly Follow this page for updates8429 visitors, last modified 25 Jan, 2020, This page is in the following categories (# of items in each category)Attached files
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