- Implications of maternal vitamin D administration for the neonatal respiratory distress syndrome: A randomized clinical trial
- 6+ VitaminDWiki pages have RESPIRATORY DISTRESS in the title
- Note: Oral Vitamin D has much faster response than injection, at far less cost
- VitaminDWiki – Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
- VitaminDWiki – Injection contains:
Implications of maternal vitamin D administration for the neonatal respiratory distress syndrome: A randomized clinical trial
J Neonatal Perinatal Med . 2024;17(2):183-190. doi: 10.3233/NPM-230158. PDF behind a paywall
H Boskabadi 1, M H Ataee Nakhaei 2, G A Maamouri 1, N Saghafi 3
Background: Vitamin D deficiency has been suggested to be a risk factor for neonatal respiratory distress syndrome (RDS). This study aimed to evaluate the effect of 25 (OH) D administrations in pregnant women with findings of preterm labor on the incidence of RDS in their preterm neonates.
Materials and methods: A randomized controlled clinical trial was conducted on pregnant mothers with gestational age (GA) of less than 34 weeks at risk of preterm delivery. 175 subjects were randomly assigned into two groups, including intervention (intramuscular injection of 50,000 units of 25(OH) D during 72 hours before delivery) and control (no injections). Serum concentrations of 25(OH) D were measured shortly after birth in both mothers and neonates. Then, clinical and laboratory results of mothers and their offspring were recorded (in a checklist). Short-term outcomes and the need for respiratory support were also assessed. Data were analyzed by independent t-test, Mann-Whitney U test, Fisher's exact test, and chi-square test.
Results: Even though gestational age, birth weight, delivery method, and serum vitamin D levels are consistent among both groups, 45% of neonates in the control group and 20% in the intervention group developed respiratory distress syndrome (P = 0.05). The mean 25(OH) D level in neonates was 17.7±10.5 and 19.29±9.94 ng/mL in the intervention and control groups, respectively (P > 0.05).
Conclusion: A single dose of 50,000 units of intramuscular 25(OH)D in pregnant women at risk of preterm labor can lower the risk of RDS in the infant.
6+ VitaminDWiki pages have RESPIRATORY DISTRESS in the title
This list is automatically updated
Note: Oral Vitamin D has much faster response than injection, at far less cost
VitaminDWiki – Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018
VitaminDWiki – Injection contains:
- Vitamin D injections last longer (3 month vs 2 month) than loading doses
- Getting Vitamin D into your body shows the many ways of getting Vitamin D
- Injections are currently made by medical professionals into muscle
- Home injection of Vitamin D appears to be possible in the future
- Injections are useful for people who might forget to take their periodic supplement (children, elderly, etc) and those who cannot swallow or have poor digestion
- While Vitamin D2 is historically the common form, Vitamin D3 is far better
- Should check (if there is time) for possible allergic reaction to Vitamin D or lack of Magnesium for both for loading dose and injection
- Note 600,000 IU Vitamin D loading dose via capsules is 1/20th the cost($2.40) of an injection, and does not require a prescription
- 100,000 IU single dose of vitamin D - 2010 has the following
- Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017 has the following
- Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies might include injection
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