Early-Onset Dementia 1.6X more likely if low Vitamin D - Dec 2023

Modifiable Risk Factors for Young-Onset Dementia Flagged

MDEdge

  • "The study included 356,052 participants younger than 65 years (mean baseline age, 54.6 years) without dementia from the UK Biobank, an ongoing prospective cohort study."
  • "During a mean follow-up of 8.12 years, there were 485 incident YOD cases (incidence rate of 16.8 per 100,000 person-years; 95% CI 15.4-18.3)."
  • "The final analysis identified 15 risk factors associated with significantly higher incidence of YOD, including traditional factors like
  • stroke (hazard ratio HR, 2.07),
  • heart disease (HR, 1.61),
  • diabetes (HR, 1.65), and
  • depression (HR, 3.25) but also less-recognized risk factors like
  • vitamin D deficiency (< 10 ng/mL; HR, 1.59),
  • high CRP levels (> 1 mg/dL; HR, 1.54),
  • and social isolation (infrequent visits to friends or family; HR, 1.53),
  • with lower socioeconomic status (HR, 1.82),
  • having two apolipoprotein E epsilon-4 alleles (HR, 1.87),
  • orthostatic hypotension, which the authors said may be an early sign of Parkinson's dementia or Lewy body dementia (HR, 4.20), and
  • hearing impairment (HR, 1.56) also increases risk."
Suspect they "adjusted" Vitamin D for stroke, diabetes, depression - all associated with Low Vitamin D

Suspect "unadjusted" Vitamin D is > 3X

Reporting on: Risk Factors for Young-Onset Dementia in the UK Biobank
Stevie Hendriks, PhD1; Janice M. Ranson, PhD2; Kirsten Peetoom, PhD1
The abstract is data-free. The PDF is not free: it costs $40 doi:10.1001/jamaneurol.2023.4929

PDF can be read at DeepDyve

7+ VitaminDWiki pages have EARLY-ONSET in the title

This list is automatically updated

Items found: 7

57+ Vitamin D pages have "Dementia" in the title

Items found: 66
Title Modified
Reduction of Post-Stroke Depression, Dementia, Delirium, and Fatigue if higher vitamin D - Aug 2025 18 Aug, 2025
Dementia prevented by Omega-3, Vitamin D, etc. book and video May 2024 01 Aug, 2025
Dementia 5X less likely if have good levels of Vitamin D, Omega-3 and Homocystine - July 2024 01 Aug, 2025
Increased dementia if increased meat - several studies 22 May, 2025
Seniors taking any amount of vitamin D reduced risk of dementia by 40% - Jan 2023 19 May, 2025
17 Ways to Cut Your Risk of Stroke, Dementia and Depression (Vitamin D cuts 10 of them) - April 2025 27 Apr, 2025
Traumatic Brain Injudry increases risk of Alzheimer's and dementia - perhaps via virus activation - Jan 2025 12 Jan, 2025
Less UV associated with more dementia - Jan 2025 07 Jan, 2025
Dementia problems: memory, financial, sleep, personality, driving, loss of smell – Sept 2024 27 Sep, 2024
Dementia risks reduced by Vitamin D – March 2023 24 Aug, 2024
Alzheimer’s, Parkinson’s, Huntington’s, dementia etc. might be prevented by vitamin D (abstract only) – Sept 2024 22 Aug, 2024
Vitamin D deficiency increases risk of Dementia by 1.4 X and Alzheimer’s by 1.5 X – Meta-analysis March 2024 11 Mar, 2024
Early-Onset Dementia 1.6X more likely if low Vitamin D - Dec 2023 12 Jan, 2024
Dementia (vascular) risk increase 60% if take Folate with other B vitamins - Dec 2023 16 Dec, 2023
The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc. 19 Aug, 2023
Poor bone health is a ‘robust’ dementia risk factor (both associated with Low vitamin D) - March 2023 31 Mar, 2023
Dementia 2.6 X more likely if very low Vitamin D – March 2023 19 Mar, 2023
The Role of Vitamin D in Reducing Risk of Alzheimer’s and Dementia - transcript Dr. Grant March 2023 12 Mar, 2023
Neurodegenerative diseases (AD, PD, MS, Dementia, etc.) fought by Vitamin D (in rodents) – Jan 2023 24 Feb, 2023
How Vitamin D fights neurodegeneration (Multiple Sclerosis, Alzheimer’s, Dementia, etc) – Jan 2023 12 Jan, 2023
Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022 06 Jan, 2023
Dementia is associated with low vitamin D - many studies 02 Jan, 2023
Dementia 1.35 X more-likely if poor diet – Oct 2022 13 Oct, 2022
Doggie dementia 6.5X more likely if not get exercise (probably low vitamin D) - Aug 2022 27 Aug, 2022
Dementia 2X more likely after ICU (suspect low Vitamin D) - Aug 2022 02 Aug, 2022
Calcitriol (activated Vitamin D) increases dementia (however, regular D decreases it) – June 2022 13 Jul, 2022
Vitamin Supplementation and Dementia - Review May 2022 11 May, 2022
Lewy Body Dementia (Robin Williams) and low Vitamin D 11 May, 2022
Dementia 10X lower in a group who are outdoors a lot and eat unprocessed foods - March 2022 07 Apr, 2022
Mild cognitive impairment is 3X more likely to become dementia in one year if low vitamin D – March 2022 07 Apr, 2022
Dementia 1.7X higher risk if diabetic and low vitamin D - Jan 2022 14 Feb, 2022
Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021 22 Nov, 2021
Dementia reduced 26 percent after pollution was reduced a decade earlier (probably higher Vitamin D) – Aug 2021 19 Aug, 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020 08 Jan, 2021
The Evidence is strong: Air pollution seems to cause dementia (perhaps low Vitamin D) – May 2019 09 May, 2019
Vitamin or Mineral Supplements Don’t Prevent Dementia (only one Vitamin D trial, it used 400 IU) – Feb 2019 04 Feb, 2019
Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018 17 Jan, 2019
Why dementia gets more severe in the winter – Jan 2019 14 Jan, 2019
Vitamin D and neurological diseases such as stroke, Vascular Dementia, PD, MS - July 2018 07 Dec, 2018
Osteoporosis in men increased their risk of Dementia by 1.3 (60,000 Germans) – July 2018 21 Aug, 2018
Dementia – clinical trial using 4,000 IU of Vitamin D– 2023 02 Aug, 2018
Dementia risk increased 2.4 X following TBI, even if had not lost consciousness – May 2018 12 May, 2018
Dementia less likely with increased levels of Magnesium etc. 18 Apr, 2018
5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 11 Apr, 2018
Off Topic: Dementia risk reduced 90 percent if woman had been highly fit 40 years before 18 Mar, 2018
Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018 16 Feb, 2018
Should you have a dementia advanced directive - Jan 2018 19 Jan, 2018
Dementia risk reduced 29 percent by just 10 hours of computer brain plasticity training – RCT Dec 2017 08 Dec, 2017
Vitamin D and Multiple Sclerosis, Alzheimer's, Parkinson's ,Dementia, and ALS - review Nov 2017 23 Nov, 2017
Heart Attack increased risk of vascular dementia by 1.35 X (both associated with low vitamin D) Oct 2017 15 Nov, 2017
Dementia risk factor is increased by 1.5 if low vitamin D – meta-analysis Jan 2017 15 Jan, 2017
Dementia 19X more likely if low vitamin D – Jan 2012 27 Oct, 2016
The "Surprising Link" Between Vitamin D Deficiency and Dementia (nope) - Oct 2015 04 Oct, 2016
The "Surprising Link" Between Vitamin D Deficiency and Dementia (not a surprise) - Oct 2015 04 Oct, 2016
Dementia risk significantly increased if have 4 chronic diseases – all associated with low vitamin D – Sept 2015 11 Dec, 2015
Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015 01 Nov, 2015
Dementia surprisingly associated with low vitamin D (should not a surprise) – Aug 2014 03 Oct, 2015
Dementia 13X more likely in elderly with low vitamin D – May 2014 04 Sep, 2015
Dementia risk increases with latitude (less vitamin D) - Feb 2015 20 Feb, 2015
Chance of Dementia increased 3 percent for every 1 ng less of vitamin D – Feb 2015 04 Feb, 2015
The Single Vitamin That's a Double Whammy Against Both Depression and Dementia (Mercola) – Aug 2014 21 Aug, 2014
More depression associated with more dementia in seniors (vitamin D not mentioned) – July 2014 31 Jul, 2014
Age-adjusted dementia may be declining – NEJM Dec 2013 01 Jan, 2014
Dementia risk increases 60 percent if have low vitamin D – Nov 2012 16 Dec, 2013
Dementia associated with low vitamin D in two thirds of studies – systematic review May 2013 01 Aug, 2013
Vitamin D might might reduce dementia – Mar 2011 23 Jun, 2012

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