Table of contents
- Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study
- VitaminDWiki - 28 studies in both categories Mortality and Cardiovascular
- VitaminDWiki - 7 studies in both categories Mortality and Breathing
- VitaminDWiki Mortality pages with CANCER in title (34 as of Oct 2022)
- VitaminDWiki - Mortality category contains
- Vitamin D Biobank study by many of the same authors - May 2021 (huge change in levels with Race and Season)
Vitamin D Deficiency Increases Mortality Risk in the UK Biobank : A Nonlinear Mendelian Randomization Study
Ann Intern Med . 2022 Oct 25.doi: 10.7326/M21-3324.
Joshua P Sutherland1 joshua.sutherland@mymail.unisa.edu.au , Ang Zhou 2 , Elina Hyppönen 2 elina.hypponen@unisa.edu.au
A few of the mortality charts: All-cause, Cardio, Respiratory, Cancer (need at least 40 ng)
Background: Low vitamin D status is associated with increased mortality, but randomized trials on severely deficient participants are lacking.
Objective: To assess genetic evidence for the causal role of low vitamin D status in mortality.
Design: Nonlinear Mendelian randomization analyses.
Setting: UK Biobank, a large-scale, prospective cohort from England, Scotland, and Wales with participants recruited between March 2006 and July 2010.
Participants: 307 601 unrelated UK Biobank participants of White European ancestry (aged 37 to 73 years at recruitment) with available measurements of 25-hydroxyvitamin D (25-(OH)D) and genetic data.
Measurements: Genetically predicted 25-(OH)D was estimated using 35 confirmed variants of 25-(OH)D. All-cause and cause-specific mortality (cardiovascular disease [CVD], cancer, and respiratory) were recorded up to June 2020.
Results: There were 18 700 deaths during the 14 years of follow-up. The association of genetically predicted 25-(OH)D with all-cause mortality was L-shaped (P for nonlinearity < 0.001), and risk for death decreased steeply with increasing concentrations until 50 nmol/L. Evidence for an association was also seen in analyses of mortality from cancer, CVD, and respiratory diseases (P ≤ 0.033 for all outcomes). Odds of all-cause mortality in the genetic analysis were estimated to increase by 25% (odds ratio, 1.25 [95% CI, 1.16 to 1.35]) for participants with a measured 25-(OH)D concentration of 25 nmol/L compared with 50 nmol/L.
Limitations: Analyses were restricted to a White European population. A genetic approach is best suited to providing proof of principle on causality, whereas the strength of the association is approximate.
Conclusion: Our study supports a causal relationship between vitamin D deficiency and mortality. Additional research needs to identify strategies that meet the National Academy of Medicine's guideline of greater than 50 nmol/L and that reduce the premature risk for death associated with low vitamin D levels.
Download the PDF from VitaminDWiki
This study underestimates the problem by about 2X by ignoring 6+ genes that reduce Vitamin D levels in blood from getting to cells
VitaminDWiki - 28 studies in both categories Mortality and Cardiovascular
This list is automatically updated
- 5X lower Cardiovascular death rate in regions consuming more fish and vegetables, (and lower obesity) – Dec 2023
- Sudden Cardiac Arrest 10.8 X more likely if severe vitamin D deficiency – May 2024
- Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024
- Risk of Cardiovascular death decreased 5X (lowest to highest Vitamin D level)- Feb 2024
- Low Vitamin D associated with CHD, stroke, death, etc, (Mendelian analhysis) - Dec 2021
- Death rates of Cardiovascular patients keep decreasing until 90 nmol of Vitamin D - May 2023
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- Metabolic Syndrome with low vitamin D increases CVD mortality by 1.7 X – July 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- 1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Omega-3 reduced cardiovascular deaths by 16 percent (427,678 people) – March 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Mortality associated with Vitamin K insufficiency (PREVEND Study) – Nov 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- 7X increased chance of death if coronary artery disease and low vitamin D – Oct 2013
- Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013
- Vitamin D protects against many types of health problems – review May 2013
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
- Predicted cardiac surgery death associated with low vitamin D levels – Dec 2012
- 3 X increased chance of death if have asthma – study of 200,000 people over 10 years – Nov 2012
- Low levels of vitamin D associated with all cause mortality – Oct 2012
- Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012
- Heart Failure early death 2X more likely if less than 20 nanograms of vitamin D – June 2012
- Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012
- Heart patients 10 percent more likely to die for every 4 ng less vitamin D – May 2011
- Did not find association between vitamin D and cardiovascular mortality – Sept 2010
- Table of outcomes for seniors vs vitamin D level
VitaminDWiki - 7 studies in both categories Mortality and Breathing
This list is automatically updated
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- COVID-19 lung death 4X more likely in Iran if less than 25 ng of vitamin D – Oct 30, 2020
- Respiratory deaths in seniors – 40 percent are attributable to low vitamin D – Aug 2020
- COVID ARDS deaths 2X more likely if less than 10 ng of Vitamin D – Aug 8, 2020
- Vitamin D predicts good health and long life in seniors, review of 20 cohort studies – Oct 2019
- 3 X increased chance of death if have asthma – study of 200,000 people over 10 years – Nov 2012
- Seniors on mechanical ventilation having very low vitamin D died sooner – July 2012
VitaminDWiki Mortality pages with CANCER in title (34 as of Oct 2022)
This list is automatically updated
VitaminDWiki - Mortality category contains
People die sooner if they have low vitamin D
click on image for details
- More vitamin D means fewer deaths – many studies
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
- Dr. Grant on vitamin D and mortality in VitaminDWiki
- Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
- Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- 4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
- Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
- Senior women having low vitamin D were 2X more likely to die - Sept 2023
- Risk of death after bone fracture was 6.6 X higher if less than 10 ng of vitamin D – June 2017
Vitamin D Biobank study by many of the same authors - May 2021 (huge change in levels with Race and Season)
Differences and determinants of vitamin D deficiency among UK biobank participants: A cross-ethnic and socioeconomic study
Clinical NutritionVolume 40, Issue 5, May 2021, Pages 3436-3447 https://doi.org/10.1016/j.clnu.2020.11.019
Joshua P.Sutherland a, AngZhou a Matthew J.Leach b ElinaHyppönen ac