Intermittent high-dose vitamin D corrects vitamin D deficiency in adolescents: a pilot study.

Eur J Clin Nutr. 2011 Dec 21. doi: 10.1038/ejcn.2011.204.
Carnes J, Quinn S, Nelson M, Jones G, Winzenberg T.
Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.

We aimed to assess the safety and efficacy of high-dose intermittent vitamin D supplementation in adolescents. Twenty-two healthy adolescents with serum 25 hydroxy-vitamin D (25-OHD) of 12.5-50?nmol/l were randomised to receive 300?000?IU or 150?000?IU of vitamin D3, or placebo orally 6-monthly for 1 year. At 12 months, the average vitamin D levels for the 300?000?IU, 150?000?IU and placebo groups were 63.0, 41.1 and 35.8?nmol/l, respectively, (P=0.004 for difference between 300?000?IU group and placebo after adjustment for age, sex and seasonal variation).

At 12 months, one participant receiving 300?000?IU was mildly deficient (25-OHD 49?nmol/l), whereas five out of six (83%) in the placebo and four out of seven participants (57%) in the 150?000?IU group remained deficient.
There were no adverse events. Compliance was high.

This suggests that 300?000?IU vitamin D3 orally 6-monthly may safely and effectively correct vitamin D deficiency in adolescents.

PMID: 22190133
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See also VitaminDWiki

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Note: other trials have found problems having such a long period between doses. The body gets too unbalanced.