Antibody response to COVID vaccination appears independent of Vitamin D levels – Nov 2021

Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults

Biomedicines. 2021 Nov 18;9(11):1714. doi: 10.3390/biomedicines9111714.
Thilo Samson Chillon 1, Kamil Demircan 1 2, Raban Arved Heller 1 3 4, Ines Maria Hirschbil-Bremer 5, Joachim Diegmann 5, Manuel Bachmann 5, Arash Moghaddam 6, Lutz Schomburg 1

The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-cholecalciferol [25(OH)D] concentrations in a cohort of healthy German adults from the time of vaccination over 24 weeks. Contrary to our expectations, no significant differences were found in the dynamic increase or decrease of SARS-CoV-2 IgG as a function of the 25(OH)D status. Furthermore, the response to the first or second vaccination, the maximum SARS-CoV-2 IgG concentrations achieved, and the decline in SARS-CoV-2 IgG concentrations over time were not related to 25(OH)D status. We conclude that the vaccination response, measured as SARS-CoV-2 IgG concentration, does not depend on 25(OH)D status in healthy adults with moderate vitamin D status.
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See also web

• Vitamin D deficiency is associated with poor response to active hepatitis B immunisation in patients with chronic kidney disease - Jan 2012 https://doi.org/10.1016/j.vaccine.2011.11.086
• Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial -Feb 2019 https://doi.org/10.3389/fimmu.2019.00065 PDF
• Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis - March 2018 no assocation PDF

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