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Antibody response to COVID vaccination appears independent of Vitamin D levels – Nov 2021

Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults

Biomedicines. 2021 Nov 18;9(11):1714. doi: 10.3390/biomedicines9111714.
Thilo Samson Chillon 1, Kamil Demircan 1 2, Raban Arved Heller 1 3 4, Ines Maria Hirschbil-Bremer 5, Joachim Diegmann 5, Manuel Bachmann 5, Arash Moghaddam 6, Lutz Schomburg 1

The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-cholecalciferol [25(OH)D] concentrations in a cohort of healthy German adults from the time of vaccination over 24 weeks. Contrary to our expectations, no significant differences were found in the dynamic increase or decrease of SARS-CoV-2 IgG as a function of the 25(OH)D status. Furthermore, the response to the first or second vaccination, the maximum SARS-CoV-2 IgG concentrations achieved, and the decline in SARS-CoV-2 IgG concentrations over time were not related to 25(OH)D status. We conclude that the vaccination response, measured as SARS-CoV-2 IgG concentration, does not depend on 25(OH)D status in healthy adults with moderate vitamin D status.
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See also web

Vitamin D deficiency is associated with poor response to active hepatitis B immunisation in patients with chronic kidney disease - Jan 2012 https://doi.org/10.1016/j.vaccine.2011.11.086
Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial -Feb 2019 https://doi.org/10.3389/fimmu.2019.00065 PDF
Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analysis - March 2018 no assocation PDF

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Antibody response to COVID vaccination appears independent of Vitamin D levels – Nov 2021

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16650	response Meta_compressed.pdf		admin 27 Nov, 2021	300.85 Kb	281	Actions View Download
16649	Influenza Vaccine Response.pdf	PDF 2019	admin 27 Nov, 2021	1.98 Mb	226	Actions View Download
16648	antibody response vs D levels_compressed.pdf	PDF 2021	admin 27 Nov, 2021	641.63 Kb	243	Actions View Download

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