- Serum inflammatory factors, vitamin D levels, and asthma severity in children with comorbid asthma and obesity/overweight: a comparative study
- 6+ VitaminDWiki Obesity pages have ASTHMA in the title
- VitaminDWiki – Overview Asthma and Vitamin D contains
- VitaminDWiki - Child Obesity and Vitamin D - many studies
Serum inflammatory factors, vitamin D levels, and asthma severity in children with comorbid asthma and obesity/overweight: a comparative study
Front. Pediatr Volume 13 - 2025 |https://doi.org/10.3389/fped.2025.1439841
Wan-yu JiangWan-yu Jiang1Rong-hong JiaoRong-hong Jiao2Su-li MaSu-li Ma1Jin-sheng DaiJin-sheng Dai1Hai-feng ZhuHai-feng Zhu1Meng-ya WuMeng-ya Wu1Yan-ran CheYan-ran Che1Lei ZhangLei Zhang1Xiao-yuan Ding
, Xiao-yuan Ding1*
1 Pediatrics Department, Shanghai Pudong New Area People’s Hospital, Shanghai, China
2 Department of Clinical Laboratory, Shanghai Pudong New Area People’s Hospital, Shanghai, China
Objective: To investigate serum inflammatory factors, vitamin D levels, and asthma severity in children with comorbid asthma and obesity/overweight, compared with those with asthma or obesity/overweight alone.
Methods: This retrospective comparative study included children suffering from asthma alone, asthma combined with obesity/overweight, or obesity/overweight alone at Shanghai Pudong New Area People's Hospital between January 2020 and December 2021.
Results: A total of 168 children (mean age: 4.32 ± 1.64 years; 117 males) were included. Compared with children with asthma alone (n = 56), those with comorbid asthma and obesity/overweight (n = 56) exhibited higher levels of serum levels of interleukin 6 (IL-6) (35.75 ± 24.56 vs. 15.40 ± 19.67), TNF-α (15.44 ± 7.35 vs. 12.16 ± 7.24), and leptin (3.89 ± 3.81 vs. 1.27 ± 2.31), and lower levels of 25-hydroxycholecalciferol (25-(OH) D3) (26.03 ± 10.77 vs. 37.15 ± 13.35), IL-10 (8.69 ± 2.76 vs. 15.32 ± 6.28), and IL-13 (449.40 ± 315.37 vs. 605.27 ± 351.02) (all P < 0.05). Compared with children with obese/overweight alone (n = 56), those with comorbid asthma and obesity/overweight had lower IL-10 (8.69 ± 2.76 vs. 12.29 ± 6.61) and higher IL-6 (35.75 ± 24.56 vs. 20.53 ± 17.07), IL-13 (449.40 ± 315.37 vs. 309.47 ± 257.45), and leptin (3.89 ± 3.81 vs. 2.48 ± 3.52) (all P < 0.05).
Children with comorbid asthma and obesity/overweight showed higher Preschool Respiratory Assessment Measure (PRAM) scores (3.14 ± 2.40 vs. 1.93 ± 1.02, P = 0.008) and longer hospital stays (5.96 ± 1.25 vs. 5.29 ± 1.36 days, P = 0.007) compared to those with asthma alone.
Conclusions: Significant differences were observed in IL-6, IL-10, IL-13, 25-(OH) D3 levels, and leptin among children with asthma combined with obesity/overweight and those with asthma or obesity/overweight alone. Children with obesity/overweight alone displayed more severe clinical manifestations and longer hospital stays compared with those with asthma alone.
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6+ VitaminDWiki Obesity pages have ASTHMA in the title
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VitaminDWiki – Overview Asthma and Vitamin D contains
- VitaminDWiki pages containing ASTHMA in title (164 as of Nov 2024)
- Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
- Started with 100,000 IU loading dose and has standard-of-care Asthma drug
- Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
- Those with Asthma or COPD had half the response to Vitamin D – March 2020
- Those with Asthma need larger doses to get the same response.
- Probably need gut-friendly Vitamin D
- CDC funded study: 1.3 X Asthma risk if vaccination contained aluminum – Sept 2022
- Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
- Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- CDC list of high-risk for COVID-19 includes Asthma
- Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
- Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
- Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Proof that Vitamin D Works 99 health problems prevented/treated as of Feb 2025
- Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
- Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
- Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
- Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
- If high vitamin D during pregnancy the child is 5X less likely to get asthma
- Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
- Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
- Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart
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