Intervention = Give Vitamin D (or Mg, Omega-3, etc) to a portion of study participants and see what happens
Typically
- Intervene with the group: one dose size, but sometimes intervene while varying the dose size
- perhaps such that each individual exceeds the desired blood level (say 40 ng)
- Group size: 50 to 500 people, but can be ~ 100,000 individuals ( Turkey- Rickets )
- Vitamin D3, but sometimes an activated form ( Calcidiol, or Calcitriol)
- Disease treatment, but sometimes disease prevention
- Just Vitamin D (monotherapy), even though cofactors are very important, especially if > 4,000 IU
Note - some interventions use loading doses to restore levels quickly (days or weeks instead of months)
Which also includes small single dose of vitamin D - say 100,000 IU
Not listed - Trials which clearly used too little vitamin D or too short of period
More than 16 reasons why Vitamin D trials fail – Oct 2020
US Clinical Trials with Vit D Intervention new since Jan 2018 453 as of Oct 2020
See also
More than 700 Intervention Trials in VitaminDWiki since the IoM decision a count of some of the trials- by health problem
Loading dose for Vitamin D
Proof that Vitamin D Works
Supplementing Vitamin D
Items in category Meta-analysis
Intervention - Vitamin D by date instead of by health problem
__Randomized Controlled Trials and Vitamin D - many studies 800+
Studies in VitaminDWiki
| Year | Randomized Controlled Trials | Interventions | Meta- analyses |
| 2022 | 900+ | 700+ | 600+ |
| 2017 | - | 48 | 52 |
| 2015 | 69 | 82 | 35 |
| 2012 | 41 | 38 | 39 |
Note: Govt recommendations in 2015 often ignored data after 2011
Intervention - sorted by date
Intervention category is associated with many others:
Intervention - non daily 232, Infant-Child 80, Pregnancy 60, Diabetes 56, Breathing 50, Loading dose 45, Virus 40, Evidence for D 35, Pain - chronic 33, Obesity 33, Cardiovascular 25, Falls and Fractures 24, Seniors 23, Injection 22, Women 21, Omega-3 21, Depression 20, Sports 20, Cognitive 19, Trauma and surgery 19, Multiple Sclerosis 18, Bone - Health 17, How much Vitamin D 17, Inflammation 17, Skin - Dark 16, Immunity 16, Hypertension 16, Better than daily 14, Gut 14, Youth 13, Liver 13, Tuberculosis 13, Kidney 13, Cost savings 12, Autism 11, High-Dose 10, Cancer - Breast 9, Cancer - after diagnosis 9, Quality of Life 9, Mortality and D 9, Deficiency of Vitamin D 9, Magnesium 9, Autoimmune 8, Optimum 8, HIV 8, Middle East 8, How, when to take Vit. D 8, Cancer - Colon 8, Overviews 7, Dental 7, Cancer 7, Genetics 7, Cystic Fibrosis 7, Fertility and sperm 7, Vitamin Calcium 7, Stroke 7, Lupus 7, Sleep 6, Fortification with Vitamin D 6, Antibiotics, probiotics 6, Thyroid and parathyroid 6, Skin 6, Cancer - Prostate 6, Metabolic Syndrome 5, Calcidiol 5, Headache 5, Osteoarthritis 5, as of Nov 2023
Detailes of associations with the Intervention category
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