Congestive Heart Failure patients helped with Vitamin D intervention – May 2013

Can Vitamin D Supplementation Improve the Severity of Congestive Heart Failure?

Congest Heart Fail. 2013 Mar 21. doi: 10.1111/chf.12026.
Amin A, Minaee S, Chitsazan M, Naderi N, Taghavi S, Ardeshiri M.
Department of Heart Failure and Transplantation, Fellowship in Heart Failure & Transplantation, Rajaei Cardiovascular, Medical and Research Center, Tehran University of Medical Sciences, Tehran, Iran.

The aim of the present study was to investigate whether vitamin D supplementation could improve biochemical findings and functional capacity of patients with heart failure (HF). One hundred patients with New York Heart Association (NYHA) class I through III HF were included in this prospective study and their 25-hydroxyvitamin D levels were evaluated. Only 6% of the participants had a sufficient serum concentration of 25(OH) D >30 nmol/L. Patients with insufficient or deficient serum levels of 25(OH) D (<30 ng/mL and <20 ng/mL, respectively) received oral vitamin D3 (cholecalciferol) for a total period of 4 months.

Vitamin D supplementation increased mean serum concentration of 25(OH) D from 12.63±7.60 nmol/L to 54.49±18.01 nmol/L (P<.001).

After vitamin D supplementation, the serum level of pro-brain natriuretic peptide markedly decreased (P<.001). Cholecalciferol significantly decreased high-sensitivity C-reactive protein level (P<.001).
Restoration of serum 25(OH) D level was also associated with substantial improvement in NYHA class (P<.001) and 6-minute walk distance (P<.001).

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PDF is attached at the bottom of this page

Intervention - not a random controlled trial

• 50,000 IU weekly for 2 months then 50,000 IU monthly for 2 months
  =7,100 daily average during loading period then 1,700 daily average for 2 months
  Started at 5 ng/ml and raised it to 22 ng/ml ( not very high. Probably should have had much higher loading and maintenance doses)

See also VitaminDWiki

• Overview Cardiovascular and vitamin D
• All items in Cardiovascular and Vitamin D 528 items
• Vitamin D augmented conventional Congestive Heart Failure treatment in perhaps 10 ways – case reports April 2017
• CHF OR {CONGESTIVE HEART FAILURE) 451 items as of April 2017
• Chronic Heart Failure not treated by Vitamin D, if dose size is ignored – meta-analysis Oct 2015
• Heart Failure and Vitamin D meta-analyses - many studies
• Congestive heart failure in infants virtually cured by 1000 IU of vitamin D – RCT Feb 2012 which has the following chart

See also web

• Relation of Vitamin D Status to Congestive Heart Failure and Cardiovascular Events in Dogs, Journal of Veterinary Internal Medicine January/February 2014
  Dogs with CHF = 40 ng, Without = 50 ng PDF is attached at the bottom of this page