Severe vitamin D deficiency upon admission in critically ill patients is related to acute kidney injury and a poor prognosis.
Med Intensiva. 2017 Aug 25. pii: S0210-5691(17)30217-6. doi: 10.1016/j.medin.2017.07.004. [Epub ahead of print], [Article in English, Spanish]
- Vitamin D and Glutamine reduced Trauma Center deaths by half – Matthews March 2017
- ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week - April 2017
- ICU death rate reduced 3X when a vitamin D injection changed the PTH – Nov 2015
- ICU survival increased with vitamin D single 540K IU loading dose - JAMA Sept 2014
Might a single dose be enough for acute Kidney injury? - Low vitamin D in Pediatric ICU – 5 times more ill (morbidity) – Spanish Nov 2016
Trauma and surgery category starts with the following
Trauma and Surgery category hasLarge dose Vitamin D before surgery was found to help by 35 studies
Vitamin D is needed before most surgeries – many studies and RCTs
4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
Sepsis is both prevented and treated by Vitamin D - many studies
Thyroidectomy and Vitamin D - many studies
Orthopaedic surgeries need Vitamin D – many studies
Cancer - After diagnosis chemotherapy
TBI OR "Traumatic Brain Injury - 21 in title as of Sept 2022
Superbug (Clostridium difficile) Infections strongly associated with low vitamin D - many studies
Glutamine and Omega-3 have also been proven to help several traumas/surgeries
Note: Vitamin D also prevents the need for various surgeries and Omega-3 prevents many concussions/TBI
Trauma and Surgery is associated with 22 other VitaminDWiki categories
Such as loading dose 33, Mortality 23, Infant-Child 21 Intervention 19 Cardiovascular 13, Injection 13 in Sept 2022
Zapatero A1, Dot I2, Diaz Y2, Gracia MP3, Pérez-Terán P2, Climent C2, Masclans JR4, Nolla J4.
- 1 Servicio de Medicina Intensiva, Hospital del Mar, Barcelona, España; Grupo de Investigación en Patología Crítica (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, España; Universitat Autònoma de Barcelona, Barcelona, España. Electronic address: 96022 at hospitaldelmar.cat.
- 2 Servicio de Medicina Intensiva, Hospital del Mar, Barcelona, España; Grupo de Investigación en Patología Crítica (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, España.
- 3 Servicio de Medicina Intensiva, Hospital del Mar, Barcelona, España; Grupo de Investigación en Patología Crítica (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, España; Universitat Autònoma de Barcelona, Barcelona, España.
- 4 Servicio de Medicina Intensiva, Hospital del Mar, Barcelona, España; Grupo de Investigación en Patología Crítica (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, España; Universitat Pompeu Fabra, Barcelona, España.
OBJECTIVES: To evaluate the prevalence of vitamin D deficiency in critically ill patients upon admission to an Intensive Care Unit (ICU) and its prognostic implications.
DESIGN: A single-center, prospective observational study was carried out from January to November 2015. Patients were followed-up on until death or hospital discharge.
SETTING: The department of Critical Care Medicine of a university hospital.
PATIENTS: All adults admitted to the ICU during the study period, without known factors capable of altering serum 25(OH)D concentration.
INTERVENTIONS: Determination of serum 25(OH)D levels within the first 24h following admission to the ICU.
MAIN VARIABLES OF INTEREST: Prevalence and mortality at 28 days.
RESULTS:
The study included 135 patients, of which 74% presented deficient serum 25(OH)D levels upon admission to the ICU. Non-survivors showed significantly lower levels than survivors (8.14ng/ml [6.17-11.53] vs. 12ng/ml [7.1-20.30]; P=.04], and the serum 25(OH)D levels were independently associated to mortality (OR 2.86; 95% CI 1.05-7.86; P=.04]. The area under the ROC curve was 0.61 (95% CI 0.51-0.75), and the best cut-off point for predicting mortality was 10.9ng/ml. Patients with serum 25(OH)D<10.9ng/ml also showed higher acute kidney injury rates (13 vs. 29%; P=.02).
CONCLUSION:
Vitamin D deficiency is highly prevalent upon admission to the ICU. Severe Vitamin D deficiency (25[OH]D<10.9ng/ml) upon admission to the ICU is associated to acute kidney injury and mortality.
PMID: 28847615 DOI: 10.1016/j.medin.2017.07.004 PDF is behind a publisher paywall
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