Multiple Sclerosis - subtle early signs – should probably take vitamin D – Feb 2017

• Overview MS and vitamin D
• Vitamin D should be taken by all MS patients - Consortium of Multiple Sclerosis Centres - April 2016
• Vitamin D prevents multiple sclerosis through multiple mechanisms – Jan 2013 Excellent, 26 pages, many good charts
• Vitamin D can both prevent and treat Multiple Sclerosis – review Nov 2012
• Multiple Sclerosis 60 percent less likely in those with more than 40 ng of vitamin D – 2006
• Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013

Overview MS and vitamin D contains the following summary
Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

• Fact: Low Vitamin D results in higher risk of getting MS
  Increase latitude leads to decreased Vitamin D, which leads to increased risk of MS
  
  
  There is less of an effect recently - air conditioning now allows people to stay indoors

  
  
  Dark skinned people are far more likely to get MS (dark skin people typically have low vitamin D)
  Elderly (who typically have low vitamin D) are more likely to get MS
  Is there increased risk in people who already have diseases associated with low vitamin D - TB, for example ? ? ?
  Women typically have 3X increased MS risk then men (note: women typically have 20% lower levels of vitamin D than men)
     Exception: women in very sunny climates and dark-skinned women have the same MS risk as men
  Obese are 60% more likely to get MS
  Multiple Sclerosis 42X more likely if light brown skin and smoke (both associated with low vitamin D) – July 2020
  MS recurrence is much higher in spring - the lowest time of the year for vitamin D
  increase in clouds/rainfall (which reduces available Vitamin D) is associated with increased risk of MS (Scotland, Western Washington)
  MS incidence has increased 70% in a decade while the incidence of vitamin D deficiency doubled
  Less MS in those with outdoor occupations PDF file, not a web page
• Fact: MS uses up Vitamin D
• Fact: Lower vitamin D (due to MS using up Vitamin D while fighting the disease) results in many other health problems (such as broken bones), so depleted vitamin D levels must be restored.
  
  Fact: Increasing levels of Vitamin D is associated with lower MS risk, as well as lower risk of many other diseases

  
• Fact: Vitamin D looks so promising for preventing and treating MS that there were 25 INTERVENTION clinical trials as of Feb 2014
• Fact: Vitamin D reduced the MS relapse rate far better than Fingolimod which is now used for that purpose.
  • Note: Fingolimod costs $25,000/year while vitamin D, which works better and has no side effects is 1000 times less expensive.
• Fact: 98% of the genes affected by Interferon are also affected by Vitamin D
  • Note: 1 week of Interferon = $4,700, 1 week of vitamin D 10,000X lower cost
• Fact: MS Doctors in Brazil recommending 40-100 ng/mL of Vitamin D
• Fact: Many MS forums are recommending vitamin D to treat MS, with some taking 5,000 to 10,000 IU daily
  Observation: Risk of going from pre-MS to MS reduced 68 percent with 7100 IU vitamin D – RCT Dec 2012
  • This is an observation instead of a fact - it has not yet been confirmed.
• Fact: VERY LARGE doses of vitamin D have CURED 2,000 people of MS in Brazil
• Controversy: UVB fron sunlight or UVB bulb may be BETTER than Vitamin D for reducing the risk of getting MS
• Hypothesis: In addition to Vitamin D there are many other photoproducts produced by UVB that may promote health.

Summary: lack of consensus on how much to prevent, treat, or cure MS.

• Coimbra Protocol (using Vitamin D) is safe and effective for Multiple Sclerosis and Autoimmune diseases – April 2022
• 54,000 IU of vitamin D daily with no Calcium (1,000 IU per kg: Coimbra protocol) – July 2024
• How much Vitamin D to prevent many diseases - such as MS
• How much Vitamin D is needed to treat MS? There is currently no agreement
     The recommendations range from 40 to 100 ng - which can result of a dose ranging from 3,000 to 20,000 IU/day
• How Vitamin D is needed to Cure MS?: It appears that 20,000-140,000 IU daily may be needed to CURE the disease
     You must be under the supervision of a doctor who knows what to watch for in your individual situation.
     High doses of Vitamin D cannot be used as a monotherapy.
     You will need to adjust the cofactors: Typically increasing Magnesium and Vitamin K2, and reducing Calcium intake.
     Your doctor will monitor these and might increase your intake of Vitamins B2, C, as well as Omega-3
• Epstein-Barr virus increases risk of Multiple Sclerosis by 32X - Jan 2022
• Multiple Sclerosis treated by Vitamin D, recommends investigating high dose Coimbra - Oct 2021
• Multiple Sclerosis patients had fewer COVID-19 problems (Note: many MSers take Vitamin D) – April 30, 2021
• Vitamin D Resistance hypothesis confirmed by Coimbra high-dose vitamin D protocol – April 2021
• Multiple Sclerosis relapses cut in half by 100,000 IU of Vitamin D every 2 weeks– RCT 2019

Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains protocol description
Vitamin D Protocol used by Dr. Coimbra for Multiple Sclerosis etc.
Snips as of April 2016 http://www.vitamindprotocol.com/dr.-coimbra-s-ms-protocol.html

• 1,000 IU's vitamin D per kilogram as a first approximation
  (apparently increased/decreased depending of resulting vitamin D blood level)
• Vitamin B2, magnesium glycinate, boron, chromium picolinate, Omega 3 DHA, Zinc, Methylcobalamin form of B12, Choline, etc.
• Lack of B12 may affect 10%–15% of the general population and may be the most prevalent genetic risk factor for several human diseases
• Discontinue eating or drinking dairy products or calcium enriched foods or beverages, also no Ca supplements
• Drink as least 2.5 liters [85 ounces] of fluids, preferably water
• Required Tests:​ Vitamin D, Parathyroid, Blood calcium, urinary calcium

Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains Facebook Groups

Facebook pages on Vitamin D and Multiple Sclerosis (original list)

• Portuguese - oldest on FB :18,788 members Jan 2017
• MS & Vitamin D - English
• English 965 members Jan 2017, 7,000 members as of May 2018
• Italian 6,570 members as of Jan 2017
• German 2,350 members as of Jan 2017 (started Sept 2016)
  Her book and protocol in German under development - perhaps Spring 2017
• Vitamin D Protocol North America 1,449 members Jan 2017

Facebook groups and pages related to Coimbra vitamin D protocol: (list added Jan 2017)

From list on Google Drives not online July 2021
English

• Vitamin D Protocol North America: https://www.facebook.com/groups/vitamindprotocolnorthamerica/
• High-Dose Vitamin D for Autoimmune Diseases: https://www.facebook.com/coimbraprotocol/*fref=nf
• Multiple Sclerosis - Vitamin D: https://www.facebook.com/groups/433972210087009/*fref=ts
• Vitamin D Multiple Sclerosis: https://www.facebook.com/Vitamin-D-Multiple-Sclerosis-156229837877670
• Vitamin D and MS: https://www.facebook.com/groups/vitamindandms 546 members as of Jan 2017
• Vitamin D Deficiency Syndrome (not only regarding autoimmune diseases, but inspired by Coimbra protocol): https://www.facebook.com/groups/120738731293512/*ref=ts&fref=ts

Brazilian/Portuguese

• ESCLEROSE MULTIPLA - O TRATAMENTO: https://www.facebook.com/groups/EscleroseMultiplaOTratamento
• ESCLEROSE MULTIPLA TEM SOLUCAO - BEMDITASVITAMINAS: https://www.facebook.com/groups/190960337581683
• Artrite Reumatoide - Tratamento com VITAMINA D: https://www.facebook.com/groups/1428810010667211
• Vitamina D - Natureza, Nutricao e Saude: https://www.facebook.com/groups/622262507873764
• Espondilite Anquilosante & D3 Vitamina: https://www.facebook.com/groups/945025008881088
• Vitamina D: https://www.facebook.com/vitaminadbrasil
• Nos dizemos ADEUS as doencas autoimunes com Vitamina D: https://www.facebook.com/groups/vitaminad
• Vitamina D e Saude: https://www.facebook.com/groups/644875738973761
• ESCLEROSE MULTIPLA + VITAMINA D = A GRANDE DESCOBERTA=VIDA ! REABILITACAO: https://www.facebook.com/groups/829851020377068
• O tratamento com vitamina D do Dr. Cicero Coimbra - Portugal: https://www.facebook.com/groups/1425762970980967
• A Brigada da Vitamina D e a Esclerose Multipla: https://www.facebook.com/vitaminadem/info

German

• Vitamin D und MS - Coimbraprotokoll: 2568 members Jan 2017
  https://www.facebook.com/groups/1584676481835203

Spanish

• Esclerosis Multiple Latinoamerica - Altas Dosis de Vitamina D 1213 members Jan 2017
  https://www.facebook.com/groups/emperu/*fref=ts
• Bendita Vitamina D: https://www.facebook.com/groups/benditavitaminad
• Esclerosis multiple - COLOMBIA - Vitamina D: https://www.facebook.com/groups/esclerosismultiplecolombiavitminad/*fref=ts
• Altas dosis de vitamina D - Esclerosis Multiple: https://www.facebook.com/Altas-dosis-de-vitamina-D-Esclerosis-M%C3%BAltiple-135790546829648

French

• Vitamine D — Pour une autre therapie: https://www.facebook.com/groups/155432754846598

Italian

• Il protocollo Coimbra in Italia - Alte dosi di vitamina D per autoimmunita: https://www.facebook.com/groups/coimbra.italia
• Per un'altra terapia - Vitamina D per la SM e per le malattie autoimmuni: https://www.facebook.com/groups/protocolloCoimbra
• Vitamina D per SM e altre"malattie autoimmuni": https://www.facebook.com/groups/348361975295212/*ref=browser
• Vitiligine & Vitamina D: https://www.facebook.com/groups/1585908351671283
• Alopecia e protocollo Coimbra: https://www.facebook.com/groups/1676891909213146/*hc_location=ufi
• Vitamina D - Emodieta- protocollo Coimbra...Guarire dalle autoimmunita: https://www.facebook.com/groups/1127525930614216/*fref=nf
• Protocollo Coimbra e Sclerosi Multipla Italia☀️ Alte dosi di vitamina D https://www.facebook.com/groups/835088713314021 455 members added March 2017

Romanian

• Pentru o alta terapie: Vitamina D pentru Scleroza Multipla: https://www.facebook.com/groups/568396633257764

Greek

• Σκλήρυνση κατά πλάκας και βιταμίνη D - Η λύση: https://www.facebook.com/groups/248517068633042

Western Balkan countries, Croatia and Slovenia 7,000 members at end of March 2017

• MS i ostale autoimune bolesti - tretman vitaminom D3: https://www.facebook.com/groups/Dvitamin/*fref=ts

Slovene

• Vitamin D3 - Cudezni hormon !: https://www.facebook.com/groups/213918382289774

Macedonian

• MS Makedonija-LEKUVANJE SO VISOKI DOZI NA D3 VITAMIN: https://www.facebook.com/groups/581798718659139/*hc_location=ufi (240 members Jan 2017)

Lithuanian

• Issetine skleroze (nauja grupe): https://www.facebook.com/groups/483705531797062

Norwegian

• Hoy dose vitamin D3 for MS og andre autoimmune tilstander : https://www.facebook.com/groups/1021897311186644
• CoimbraProtokollen - Informasjon Norge https://www.facebook.com/coimbraprotokollen/ noticed May 2017

Serbian:

• https://www.facebook.com/groups/Dvitamin/*ref=bookmarks (6200 members Jan 2017)
• https://www.facebook.com/groups/msd3tretman/*ref=bookmarks (350 members Jan 2017)

Russian added Feb 2017

• https://www.facebook.com/groups/protokolvitamind/

Some Facebook pages on just Vitamin D

• Vitamin D Wellness 12,689 members as of Jan 2017
• Vitamin D Deficiency and Treatment 7,075 members as of Jan 2017
• Vitamina D Brazil