Transpl Immunol . 2021 May 18;101410. doi: 10.1016/j.trim.2021.101410
Mohammad Mirzakhani 1, Sheyda Mohammadkhani 2, Shirin Hekmatirad 3, Soudabeh Aghapour 4, Negar Gorjizadeh 5, Mehdi Shahbazi 6, Mousa Mohammadnia-Afrouzi 7
Kidney transplant worked better if initially have high level of vitamin D – April 2012
Kidney category starts with
Overview Kidney and vitamin D contains the following summary
- FACT: The Kidneys are not the primary way to activate vitamin D; the tissues are
- FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
- FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
- FACT: There are many ongoing intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
- FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
- FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
- FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
- Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
Nanoemulstion vitamin D (inside cheek, topically) gets activated Vitamin D to the cells without the need for healthy kidney, liver, or intestine
Calcitriol - which bypasses the need for the kidney to activate vitamin D
Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
- Category Kidney and Vitamin D contains 237 items
Download the PDF from VitaminDWiki
Background: Vitamin D (VitD) deficiency is associated with several diseases such as multiple sclerosis, rheumatoid arthritis, respiratory infection, and so forth. In the field of transplantation (kidney transplantation), some studies reported that patients with VitD deficiency are of increased chance of acute rejection, but other studies did not show such a chance. On the other hand, since VitD is a modulatory factor and can reduce the inflammatory response, understanding the exact role of it in transplantation may contribute to tolerance condition in these patients.
Methods: The electronic databases, including PubMed, Scopus, Embase, ProQuest, Web of Science, and Google Scholar, were searched for eligible studies. In general, 14 studies with a total of 4770 patients were included in this meta-analysis. Regarding the methodological heterogeneity, we selected a random-effects combination model. Moreover, OR was chosen as an effect size for this study.
Results: After the combination of 14 studies, we showed that patients in the VitD-deficient group had an 82% increased chance of acute rejection compared with patients in the VitD-sufficient group, and this effect was significant (OR 1.82; 95% confidence interval [CI] [1.29, 2.56]; I2 = 52.3%). This result was significant, and, regarding the narrow CI, it can be a conclusive result. Study quality and gender variables were the main sources of inconsistent results in the primary studies. Moreover, using meta-regression, we showed that VitD deficiency (independent from the estimated glomerular filtration rate (eGFR) of patients) increased the chance of acute rejection.
Conclusion: The normal VitD status of patients a few days before and after transplantation can reduce the chance of acute rejection.
Vitamin D page titles containing the word "transplant"
Items found: 39
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New case of diabetes 2X more likely after kidney transplant if low Vitamin D – March 2025 |
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08 Mar, 2025 |
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Lung transplant survival 4X more likely if take 2,000 IU of vitamin D daily – Oct 2024 |
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28 Oct, 2024 |
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Fecal transplants finally approved to fight C.difficile – July 2024 |
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07 Oct, 2024 |
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Vitamin D would probably help both CKD and Kidney transplant (PDF behind paywall) – Sept 2024 |
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03 Sep, 2024 |
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Autism risky if low vitamin D during pregnancy and early life (mice, fecal transplant reversed it) – March 2024 |
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27 Mar, 2024 |
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Vitamin D helps organ transplant - many studies |
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30 Nov, 2023 |
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Liver transplant failure 2.7X more-likely if low vitamin D - Nov 2023 |
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30 Nov, 2023 |
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Vitamin D 100,000 IU loading dose and stem cell transplants – RCT Oct 2023 |
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31 Oct, 2023 |
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Fecal transplants - many studies |
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26 Apr, 2023 |
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Fracture 4X less likely following kidney transplant if high-dose Vitamin D (100,000 every 2 weeks) – RCT Jan 2023 |
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25 Jan, 2023 |
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Fecal transplant from young reduced age-associated defects in old (mice so far) – Aug 2021 |
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27 Aug, 2021 |
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Liver transplants in children more likely to be rejected if insufficient vitamin D – Aug 2021 |
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07 Aug, 2021 |
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Very low Vitamin D levels after Liver transplant in children (need Calcitriol or topical) – May 2021 |
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03 Jun, 2021 |
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Kidney transplant rejection 1.8X more likely if low vitamin D – May 2021 |
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22 May, 2021 |
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1,000 IU of vitamin D provides little benefit (Kidney transplant in this case) – April 2021 |
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22 Apr, 2021 |
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Organ Transplant patients probably need more UV and or vitamin D April 2010 |
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24 Mar, 2021 |
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If you are getting a lung transplant you must have vitamin D - April 2012 |
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24 Mar, 2021 |
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Omega-3 reduced pancreas transplant failure by 3X and sepsis by 2X – review Dec 2019 |
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18 Dec, 2019 |
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Stem cell transplant (HSCT) patients are dying due to lack of vitamin D – Oct 2019 |
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28 Oct, 2019 |
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Stem Cell Transplants consume vitamin D – July 2011 |
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23 Oct, 2019 |
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Stem cell transplant (HSCT). death 28 percent less likely for each 10ng higher vitamin D level – Oct 2019 |
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23 Oct, 2019 |
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4X reduction in bone fractures following Kidney Transplant with monthly Vitamin D (100,000 IU) - RCT June 2019 |
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17 Jun, 2019 |
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Fecal transplants increased Vitamin D levels (germ-free mice) – March 2018 |
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29 Jun, 2018 |
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Liver transplant needs Vitamin D (actually semi-activated, not regular) – May 2017 |
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27 May, 2017 |
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Bone marrow transplant – like other traumas – lowers vitamin D levels – July 2011 |
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17 Apr, 2017 |
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Vitamin D may help after organ transplant – if can give enough – Jan 2011 |
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25 Mar, 2017 |
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4X fewer malignancies after kidney transplant if got active vitamin D – Prospective Score Sept 2012 |
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25 Mar, 2017 |
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Kidney transplant patients advised to avoid the sun, then 90% have very low vitamin D levels – Sept 2012 |
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25 Mar, 2017 |
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Vitamin D and biophospates are needed after organ transplant – Aug 2011 |
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25 Mar, 2017 |
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Calcitriol (active Vitamin D) recommended after kidney transplant – March 2014 |
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28 Apr, 2016 |
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Active form of vitamin D (calcitriol) cut in half the fractures following organ transplant – meta-analysis Aug 2011 |
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26 Jul, 2015 |
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Gut, Alzheimer, autism, disease, fecal transplant, etc - Dr. Perlmutter, May 2015 |
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18 May, 2015 |
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400,000 IU barely raised liver transplant candidate vitamin D levels (no surprise) – March 2015 |
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26 Mar, 2015 |
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Even with vitamin D supplementation Kidney transplant patients were deficient – Jan 2011 |
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28 Aug, 2012 |
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Babies Receive Heart Transplants Instead of Vitamin D Treatment |
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25 Jun, 2012 |
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Kidney transplant worked better if initially have high level of vitamin D – April 2012 |
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28 Apr, 2012 |
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Vitamin D levels low both before and after organ transplant July 2011 |
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27 Apr, 2012 |
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Heart transplant 19 ng vitamin D vs liver transplant 13 ng – April 2009 |
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12 Nov, 2011 |
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Many Organ transplants cause skin cancer – what is the role of UV – Feb 2012 |
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