Liposomal Glutathione: Tolerance and Potential Problems
General Safety
Liposomal glutathione is generally recognized as safe and is often better tolerated than standard glutathione tablets or capsules, which can cause gastric discomfort in people with sensitive stomachs 1. Most people do not experience significant side effects when taking liposomal glutathione at recommended doses 1 8.
Possible Side Effects
However, some individuals may experience problems, including:
- Gastrointestinal Issues: Even with the liposomal form, some people may have mild stomach upset, such as bloating, cramps, nausea, or diarrhea, especially at higher doses 4 5 6 7 8.
- Allergic Reactions: Rarely, allergic reactions can occur. Symptoms may include skin rashes, itching, swelling (especially of the face, lips, or throat), or difficulty breathing. These reactions require immediate medical attention and discontinuation of the supplement 6 7.
- Headaches: Some individuals report headaches, though the cause is not fully understood 7.
- Altered Mineral Levels: Long-term glutathione supplementation has been linked to lower zinc levels in some cases 2 7.
- Breathing Difficulties: People with asthma or respiratory sensitivities should be cautious, as glutathione (especially inhaled forms) can sometimes trigger breathing problems 2 6 9 11.
Individual Sensitivities
- Genetic Factors: Some people may have genetic variations (such as certain "snips") that make them more sensitive to glutathione, requiring them to start with very small doses 8.
- Pre-existing Conditions: Those with allergies to glutathione or any of its components, or with certain medical conditions (like asthma), should avoid use or consult a healthcare provider before starting supplementation 2 6 11.
Precautions
- Pregnancy and Breastfeeding: There is not enough reliable information about the safety of glutathione supplementation during pregnancy or breastfeeding, so it is generally advised to avoid use in these populations 2 7 11.
- Drug Interactions: Glutathione may interact with certain medications, such as nitroglycerin, nitrates, and chemotherapy drugs, potentially affecting their efficacy or increasing side effects 6.
Summary Table: Potential Problems with Liposomal Glutathione
| Problem/Side Effect | Frequency/Notes |
| Stomach upset (bloating, cramps, diarrhea) | Mild, more likely at higher doses 4 5 6 8 |
| Allergic reactions | Rare, can be serious (rash, swelling, breathing issues) 6 7 |
| Headaches | Occasionally reported 7 |
| Lower zinc levels | Possible with long-term use 2 7 |
| Breathing difficulties (especially inhaled) | Caution for people with asthma 2 6 9 11 |
| Drug interactions | Possible with some medications 6 |
| Unknown safety in pregnancy/breastfeeding | Avoid use 2 7 11 |
Conclusion
While most people tolerate liposomal glutathione well, some may experience gastrointestinal discomfort, allergic reactions, headaches, or other issues—especially those with certain genetic sensitivities, allergies, or pre-existing conditions. Always consult a healthcare provider before starting supplementation, particularly if you have underlying health concerns or are taking other medications 2 6 7 8.
References
- https://victoriahealth.com/editorial/liposomal-glutathione-benefits-side-effects
- https://www.webmd.com/vitamins-and-supplements/glutathione-uses-risks
- https://www.healthline.com/health/glutathione-benefits
- https://synapse.patsnap.com/article/what-are-the-side-effects-of-glutathione
- https://www.invigormedical.com/lifestyle/glutathione-side-effects/
- https://biomprobiotics.com/what-to-avoid-when-taking-glutathione-a-guide-to-safe-supplementation/
- https://naturesfix.co.uk/blog/glutathione/side-effects-of-glutathione/
- https://www.researchednutritionals.com/why-do-we-need-liposomal-glutathione/
- https://www.verywellhealth.com/benefits-of-glutathione-89457
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6389332/
- https://www.webmd.com/vitamins/ai/ingredientmono-717/glutathione
- https://www.uclahealth.org/news/article/ask-the-doctors-what-do-glutathione-supplements-do
- https://bodybio.com/blogs/blog/what-is-liposomal-glutathione
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5413479/
Less than 1% of problems taking liposomal glutathione
Based on available clinical data, the percentage of people who experience problems taking liposomal glutathione is very low. In a published clinical trial specifically examining oral liposomal glutathione, no serious adverse effects were reported, and all potential adverse events were minor and not attributed to the treatment. Compliance in the study was high, and less than 1.5% of scheduled doses were missed, suggesting that side effects significant enough to cause discontinuation are rare 1.
Other reviews and safety summaries confirm that glutathione is generally well tolerated, with only a few people developing mild adverse reactions such as loose stools, increased flatulence, or weight gain 5. These reactions are uncommon and not typically severe. Larger reviews and clinical experiences suggest that the rate of adverse effects is well below 10%, and likely closer to or below 1% for significant problems 1 5.
In summary, the available evidence suggests that fewer than 1% of people have problems taking liposomal glutathione, with most side effects being minor and infrequent 1 5.
References
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6389332/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5413479/
- https://www.sciencedirect.com/science/article/pii/S2405844019358220
- https://www.webmd.com/vitamins/ai/ingredientmono-717/glutathione
- https://longevity.technology/lifestyle/the-ultimate-guide-to-glutathione-benefits-side-effects-research/
- https://ijdvl.com/glutathione-as-a-skin-whitening-agent-facts-myths-evidence-and-controversies/
- https://www.pagepressjournals.org/gc/article/view/10390/10460
- https://fullscript.com/blog/glutathione-supplements
See also Glutathione