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Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT July 2015

Effect of Vitamin D supplementation on symptoms and C-reactive protein in migraine patients

Journal of Research in Medical Sciences
Tayebeh Mottaghi, Gholamreza Askari, Fariborz Khorvash, Mohammad Reza Maracy

Background: Migarine is the most common headache around the world including Iran. In recent years, Vitamin D deficiency has been shown to a global health problem. A few studies have been determined inverse association between serum levels of Vitamin D with a headache. So, in this study, we investigated the effect of Vitamin D supplementation on symptoms and C-reactive protein(CRP) among patients with migraine.

Materials and Methods: This study was randomized, double-blind, and controlled-placebo clinical trial. Sixty-five migraine patients aged 10-61 years were included for analysis. Vitamin D was administrated for 10 weeks with 50,000 IU dosage of Vitamin D per week. Multivariate analysis of covariate and univariate analysis of covariate were done to determine the effects of Vitamin D supplementation on symptoms, including severity, duration, frequency of headache, and the headache diary result (HDR).

Results: Mean headache frequency and HDR had significant difference among two groups (5.9 ± 7.0 vs. 7.0 ± 6.0, P = 0.06 and 85.0 ± 134.2 vs. 132.1 ± 147.1, P = 0.04). But, a mean difference of headache frequency was marginally significant (P = 0.06). These values were lower among the intervention group compared to placebo group. The association was not observed between CRP with migraine disease.

Conclusion: In this study, we shown Vitamin D supplementation may be useful in decreasing frequency of headache attacks and HDR among patients with migraine.

See also VitaminDWiki

Headaches helped by Vitamin D in 7 studies – Jan 2020
Pages listed in BOTH the categories Headache and Magnesium

Headache category listing has 50 items along with related searches which has the following

Migraine Headaches associated with metal excess/deficiencies - July 2015
Compared blood levels of 25 with migraines to 25 without

Metal Migraine No Migraine Ratio
Cadmium 0.36 ug 0.09 ug 4X MORE
Iron 0.97 ug 0.48 ug 2X MORE
Lead 1.48 ug 0.78 ug 2X MORE
Magnesium 10.6 ug 34.5 ug 3.5X LESS
Zinc 0.24 ug 5.77 ug 24X LESS

Zinc and Vitamin D category listing has 95 items along with related searches

Speculation by VitaminDWiki
Significant migraine reduction if use 10,000 IU of vitamin D, Magnesium, and perhaps Zinc

Cadmium liver problem 5 X less likely when vitamin D is greater than 40 ng – April 2018
The study found 5X fever Cadium lever problems with vitamin D > 40 ng

See also web

Vitamin D supplementation may help patients with migraines, according to RCT
Vitamin D Council on this same study

Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT July 2015

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- One pill every two weeks gives you all the vitamin D most adults need Migraine headaches cut in half by 4,000 IU of vitamin D – RCT Sept 2018 Depression greatly reduced by taking 250 mg of Magnesium Chloride daily for 6 weeks– RCT June 2017 If you have a vitamin D prescription, be sure that it is for D3– June 2017 50,000 IU Vitamin D weekly was the most popular for Breast Cancer - May 2020 Headaches helped by Vitamin D in 7 studies – Jan 2020 Cadmium liver problem 5 X less likely when vitamin D is greater than 40 ng – April 2018 Migraine headache 5X less likely if optimal level of vitamin D – Oct 2018 Chronic migraine headaches 1.4 X more likely with low vitamin D – July 2018 Migraines double the risk of strokes (both are associated with low vitamin D) – Jan 2018 Fewer headaches and other benefits of higher vitamin D – Jan 2017 Vitamin D and Migraine – Nov 2010

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Headache 48 Intervention 824 Zinc 95 Intervention - non daily 270

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