Omega-6 blocks Omega-3 etc. -many studies

---

Asked ChatGPT: How does Omega-6 block Omega-3- Dec 2023

Omega-6 and omega-3 fatty acids are both essential polyunsaturated fats that play important roles in the body. However, they have different effects and their balance in the diet is crucial for maintaining good health. Here's how omega-6 can interfere with omega-3:

1. Competitive Metabolism: Both omega-6 and omega-3 fatty acids use the same enzymes for their metabolism in the body. Omega-6 fatty acids are metabolized by the enzyme delta-6-desaturase, which is also used by omega-3 fatty acids. When the diet is high in omega-6, these fatty acids compete for the same metabolic enzymes, reducing the amount available for omega-3 metabolism. This competition can limit the body's ability to convert alpha-linolenic acid (ALA), a type of omega-3, into its more active forms, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
2. Inflammatory Balance: Omega-6 fatty acids, particularly arachidonic acid (AA), can lead to the production of pro-inflammatory eicosanoids, which are signaling molecules. In contrast, omega-3 fatty acids, particularly EPA, produce anti-inflammatory eicosanoids. A high intake of omega-6 relative to omega-3 can shift the body's balance towards a more pro-inflammatory state, which is linked to various chronic diseases.
3. Cell Membrane Composition: Both types of fatty acids are incorporated into cell membranes. A diet high in omega-6 fatty acids can alter the composition of cell membranes, potentially affecting cell function and signaling.
4. Chronic Diseases and Health Effects: An imbalance favoring omega-6 over omega-3 has been associated with an increased risk of chronic diseases such as heart disease, inflammatory diseases, and certain cancers. It is suggested that a lower omega-6 to omega-3 ratio is more desirable in reducing the risk of these diseases.

To verify and expand upon this information, let me find some references for you.
Omega-6 and omega-3 fatty acids are essential polyunsaturated fats that are crucial for human health, but their interaction and the balance between them are complex and have significant implications. Here's a summary of the key findings from various studies:

1. General Health Impact: Omega-6 and omega-3 fatty acids are known to influence oxidative stress and inflammation, which are key factors in the risk of chronic non-communicable diseases URL
2. Cardiovascular Health: There's been a growing interest in the health effects of long-chain omega-3 fatty acids, particularly regarding cardiovascular and neurocognitive diseases. The balance of omega-6 and omega-3 fatty acids is crucial here, but determining the "optimal" levels of these fatty acids is not straightforward due to various factors in measurement and expression. URL
   Also, studies have shown the beneficial effects of omega-3 fatty acids, like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on cardiovascular outcomes, although there's some variability in the treatment effects of EPA vs. EPA+DHA URL
3. Prevention of Atherosclerotic Cardiovascular Disease: Observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease. However, randomized controlled trials have often reported neutral findings, suggesting a more complex relationship between these fatty acids and heart health URL
4. Dietary Imbalance and Health Effects: There has been a significant change in our diets, with an increase in consumption of vegetable oils rich in omega-6 and a depletion of omega-3 fatty acids, leading to an imbalance. This dietary shift has important implications for health, particularly in relation to glucose metabolism and possibly other metabolic processes URL
5. Cancer Risk: The relationship between long-chain omega-3, alpha-linolenic acid (ALA), omega-6, and total polyunsaturated fatty acid (PUFA) intakes and cancer risk is still unclear. More research is needed to fully understand how these fatty acids might influence cancer development and progression URL

In summary, both omega-6 and omega-3 fatty acids are vital for health, but their balance is critical. High consumption of omega-6, relative to omega-3, can lead to adverse health outcomes due to competitive metabolism, inflammatory balance, and altered cell

---

Asked Perplexity the same question - April 2025

 Download the PDF from VitaminDWiki

---

11+ VitaminDWiki pages with OMEGA-6 in the title

This list is automatically updated

---

High Omega-6 vs Omega-3 increases all cause mortality by ~ 1.3 X - April 2025

Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: A population-based cohort study in UK Biobank
eLife digest https://doi.org/10.7554/eLife.90132.3
Yuchen ZhangYitang SunQi YuSuhang SongJ Thomas BrennaYe Shen

Background:
Circulating omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) have been associated with various chronic diseases and mortality, but results are conflicting. Few studies examined the role of omega-6/omega-3 ratio in mortality.

Methods:
We investigated plasma omega-3 and omega-6 PUFAs and their ratio in relation to all-cause and cause-specific mortality in a large prospective cohort, the UK Biobank. Of 85,425 participants who had complete information on circulating PUFAs, 6461 died during follow-up, including 2794 from cancer and 1668 from cardiovascular disease (CVD). Associations were estimated by multivariable Cox proportional hazards regression with adjustment for relevant risk factors.

Results:
Risk for all three mortality outcomes increased as the ratio of omega-6/omega-3 PUFAs increased (all Ptrend <0.05). Comparing the highest to the lowest quintiles, individuals had

• 26% (95% CI, 15–38%) higher total mortality,
• 14% (95% CI, 0–31%) higher cancer mortality, and
• 31% (95% CI, 10–55%) higher CVD mortality.

Moreover, omega-3 and omega-6 PUFAs in plasma were all inversely associated with all-cause, cancer, and CVD mortality, with omega-3 showing stronger effects.

Conclusions:
Using a population-based cohort in UK Biobank, our study revealed a strong association between the ratio of circulating omega-6/omega-3 PUFAs and the risk of all-cause, cancer, and CVD mortality.
 Download the PDF from VitaminDWiki

---

The Simplest Way to Balance the Omega-6 to Omega-3 Ratio - video Dec 2022

Dr. Berg 5 minutes
0:00 Introduction: Understanding the omega-6 to omega-3 ratio
1:07 Are omega-6 fatty acids bad?
3:00 How to balance your omega-fatty acid ratio
5:25 Learn more about cod liver oil!

---

Seed Oils Stored in Fat Cells Driving Inflammation - video Feb 2024

YouTube 29 minutes
Ai says: Seed oils such as sunflower, corn, soybean, and cottonseed oils are among the highest in omega-6 content

• One of his references: Increase in Adipose Tissue Linoleic Acid of US Adults in the Last Half Century - 2015 doi: 10.3945/an.115.009944 FREE PDF

---

Linoleic acid (Omega-6) increased intake, many health problems – Mercola July 2023

Linoleic Acid: A Narrative Review of the Effects of Increased Intake in the Standard American Diet and Associations with Chronic Disease
Journals Nutrients Volume 15 Issue 14 10.3390/nu15143129
by Joseph Mercola 1,* and Christopher R. D’Adamo 2ORCID
1 Natural Health Partners, LLC, 125 SW 3rd Place, Cape Coral, FL 33991, USA
2 Dept of Family and Community Medicine, Center for Integrative Medicine, U. of Maryland School of Medicine, Baltimore, MD 21201, USA

Table of Contents

Linoleic acid (LA) intake has increased dramatically in the standard American diet. LA is generally promoted as supporting human health, but there exists controversy regarding whether the amount of LA currently consumed in the standard American diet supports human health. The goal of this narrative review is to explore the mechanisms that underlie the hypothesis that excessive LA intake may harm human health.
While LA is considered to be an essential fatty acid and supports health when consumed in modest amounts, an excessive intake of LA leads to the formation of oxidized linoleic acid metabolites (OXLAMs), impairments in mitochondrial function through suboptimal cardiolipin composition. It likely contributes to many chronic diseases that became an epidemic in the 20th century and whose prevalence continues to increase.
The standard American diet comprises 14 to 25 times more omega-6 than omega-3 fatty acids, with most omega-6 intake coming from LA. As LA consumption increases, the potential for OXLAM formation also increases. OXLAMs have been associated with various illnesses, including cardiovascular disease, cancer, and Alzheimer’s disease, among others. Lowering dietary LA intake can help reduce the production and accumulation of OXLAMs implicated in chronic diseases.
While there are other problematic components in the standard American diet, the half-life of LA is approximately two years, which means the damage can be far more persistent than other dietary factors, and the impact of reducing excessive LA intake takes time. Therefore, additional research-evaluating approaches to reduce OXLAM formation and cardiolipin derangements following LA consumption are warranted.
 Download the PDF from VitaminDWiki

---

Linoleic Acid — The Most Destructive Ingredient in Your Diet - Video - by the author of the study

32 minute video

STORY AT-A-GLANCE

• Fats are the primary building block of your cell membranes. This is one of the reasons why eating the right types of fat is so important for your health and longevity
• While most nutritional experts blame the epidemic of chronic disease on the increase in sugar consumption, the role of sugar is relatively minor when compared to the impact of seed oils
• based on how many of their carbon bonds are paired with hydrogen, there are two basic types of fatty acids: saturated fats and unsaturated fats. Unsaturated fats are further subdivided into monounsaturated fats and polyunsaturated fats (PUFAs), depending on how many pairs of hydrogen atoms they are missing
• Because your tissues are made up mostly of saturated and monounsaturated fats, your body requires more of them than PUFAs
• The main dietary PUFAs are omega-3 and omega-6 fats, and while your body does need these, it needs them in relatively small quantities. The most pernicious toxin in the modern diet, and the fat you need to minimize consumption of, is the omega-6 fat linoleic acid (LA). LA makes up 60% to 80% of omega-6 fats and is the primary contributor to chronic disease

Commonly Confused Fats

• It is also important to highlight a primarily plant-based omega-3 fat called alpha-linolenic acid (ALA). ALA should be distinct from LA, as they differ from a biological standpoint. LA is an omega-6 fat, and ALA is an omega-3 fat.
• do not confuse LA with CLA (conjugated linoleic acid). Although CLA is an omega-6 fat, and most think CLA and LA are interchangeable, they're not. CLA has many potent health benefits and will not cause the problems that LA does.
• up to 50% or more of the overall calories in most processed foods come from seed oils.1
• You have about 40 quadrillion to 100 quadrillion mitochondria throughout your body's cells.
  • In 37 trillion cells - it appears that there are ~1000 mitochondria per cell - average.

ALEs and OXLAMs can also:

• Damage the cells lining your blood vessels
• Cause memory impairment and increases your risk of Alzheimer’s disease (canola oil, in particular, has been linked to Alzheimer’s)
• Strip your liver of glutathione thereby lowering your antioxidant defenses
• Inhibit delta-6 desaturase (delta-6), an enzyme involved in the conversion of short-chained omega-3s to longer chained omega-3s in your liver
• Impair your immune function and increase mortality
• Make your fat cells more insulin sensitive, thereby causing insulin resistance
• Inhibit cardiolipin, an important fat in the inner membrane of your mitochondria

---

Mercola is against Omega-6 which blocks Omega-3

Video and lots of text - Dec 2022

Linoleic Acid — The Most Destructive Ingredient in Your Diet - May 2023 video and text

Founder of VitaminDWiki was unable to get his Omega-3 index up to 8 until he reduced his Omega-6 consumption and switched to an emulsified form

---

VitaminDWiki - Omega-3 helps many health problems

413 Omega-3 items in category Omega-3 helps with: Autism (7 studies), Depression (28 studies), Cardiovascular (34 studies), Cognition (52 studies), Pregnancy (46 studies), Infant (34 studies), Obesity (14 studies), Mortality (7 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (19 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
CIlck here for details

---

VitaminDWiki – Vitamin D and Omega-3 highlights:

Cognitive 48, Pregnancy 39, Cardiovascular 32, Magnesium 31, Infant-Child 31, Depression 29, Meta-analysis 22, Zinc 22, Intervention 21, Inflammation 18, Sports 16, Vitamin K 15, Obesity 13, Trauma and surgery 12, Virus 12, Diabetes 11, Supplement 10, Multiple Sclerosis 9, Seniors 9, ADHD 9, Iron 9, Autism 8, Iodine 8, Vitamin B12, 8 Sleep 7, Women 7, Resveratrol 7, Boron 6, Cancer - Breast 6, Curcumin 6, Vitamin A 6, Liver 6, Cancer - Prostate 5, Vitamin C 5, Mortality 5, Antibiotics, probiotics 4, Hypertension 4, Veterinary 4, Cancer - after diagnosis 4, Rheumatoid Arthritis 4, Metabolic Syndrome 4

     As of May 2023       Click below to see detailed associations

---

See also web

• 61 Health Benefits of Omega-3 Fatty Acids June 2012
• Health aspects of regular consumption of fish and omega-3-fatty acids - Sept 2015
  No such attachment on this page
• Organic Meats have 50% more Omega-3 - meta-analysis Feb 2016 NYT
  switching to organic meats only adds about 50 mg of Omega-3 - which is not very much
  And Omega-6 was slightly lower in organic meats