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Prediabetic have very different gut bacteria – March 2015

Prediabetes Patients Have Fewer Gut Bugs MedPageToday

News Release for Endocrinology Conference
Significant Differences in Fecal Microbiota Are Associated with Various Stages of Glucose Tolerance in African-American Male Veterans

African American men divided into 4 groups

stable glucose tolerance,
stable impaired fasting glucose
or stable impaired glucose tolerance,
worsened glucose tolerance
improved glucose tolerance.

There were significant differences in bacterial composition between the first and second groups (P=0.03) at the phylum level. Bacteroidetes was higher and Firmicutes was lower with worse glycemic control in the second group.

The Bacteroidetes/Firmicutes ratio was 1.9 versus 0.9 in group 1 and 2 (P=0.01) and 1.9 versus 1.1 in group 1 and 3 (P=0.04).
Proteobacteria decreased over the period in groups 2 and 4 compared to group 1 (P=0.04 for both).
At the family and genus levels, in group 2 versus group 1 there was less Prevotella, and a higher Bacteroides/Prevotella ratio in the second group at 5.6 to 2.7 (P=0.05). There was also less Enterobacteriacea (P=0.03), and more Ruminococcae (P=0.01) and Veillonelacea (P=0.02).

"We speculate that lower abundance of Prevotella may be associated with worsening glycemia, and conversely higher abundance of Akkermansia might be associated with improving glycemia, thus corroborating suggestions from previous studies,"

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Antibiotics, probiotics category listing has 93 items along with related searches
Antibiotics and Vitamin D are associated with many of the same diseases
Exploring gut microbes in Human health and disease: pushing the envelope - Aug 2014

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Prediabetic have very different gut bacteria – March 2015

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- Gut microbiome massively changed by weekly vitamin D – July 2015 Gut microbiome altered by many nutrients – such as Vitamin D – Jan 2020 Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015 Vitamin D (10,000 IU) changes bacteria in the gut – RCT Jan 2020 Good gut diversity if Ultraviolet Light or if supplement with Vitamin D– Oct 2019 Vitamin D deficiency is associated with prediabetes in obese Swedish children – Oct 2016 Fecal transplants increased Vitamin D levels (germ-free mice) – March 2018 Hypothesis: vitamin D and probiotics will reduce type II diabetes – Jan 2013 Diabetes risk increased by 50 percent if had 5 courses of antibiotics – Aug 2015 Off topic - Parkinson’s Disease changes gut bacteria – March 2015 Gut, Alzheimer, autism, disease, fecal transplant, etc - Dr. Perlmutter, May 2015

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