Association between circulating 25-hydroxyvitamin D levels and psoriasis, and correlation with disease severity: a meta-analysis.
Clin Exp Dermatol. 2018 Jan 16. doi: 10.1111/ced.13381. [Epub ahead of print]
Lee YH1, Song GG1.
- Psoriasis proven to be treated by Vitamin D in many RCT, but dermatologists fear losing business – March 2015
- Ultraviolet light (which produces vitamin D) decreased the use of psoriasis drugs for a year – Aug 2017
- Psorasis treatment helped by Vitamin D – Cochrane March 2013
- How UVB reduces autoimmune diseases such as Multiple Sclerosis – April 2014
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BACKGROUND:
Psoriasis is a chronic, autoimmune, inflammatory skin disorder. 25-hydroxy vitamin D [25(OH)D] deficiency may contribute to the pathogenesis of psoriasis through reduction in antiproliferative, anti-inflammatory and antiangiogenic activities.
AIM:
To evaluate the relationship between circulating 25(OH)D levels and psoriasis, and to determine the correlation between serum/plasma 25(OH)D levels and psoriasis severity.
METHODS:
We performed a meta-analysis to compare serum/plasma 25(OH)D levels between patients with psoriasis and healthy controls (HCs), and to determine the correlation coefficients between circulating 25(OH)D levels and psoriasis severity as assessed by Psoriasis Area and Severity Index (PASI).
RESULTS:
Ten articles with a total of 571 patients with psoriasis and 496 HCs were included. The 25(OH)D level was significantly lower in the psoriasis group than in the HC group. Subgroup analysis by sample size revealed a significantly lower level of 25(OH)D in the psoriasis group for large (N > 80) but not for small (N < 80) sample sizes.
Stratification by adjustment for age and/or sex or sample type revealed a significantly lower 25(OH)D level in the psoriasis group after adjustment for serum but not after nonadjustment for plasma.
Meta-analysis of the correlation coefficients revealed a small but statistically significant positive correlation between circulating 25(OH)D levels and PASI.
CONCLUSIONS:
This meta-analysis demonstrated that circulating 25(OH)D levels are lower in patients with psoriasis, and that a small but statistically significant negative correlation exists between 25(OH)D levels and psoriasis severity.
Psoriasis in VitaminDWiki
Some of the- Psoriasis is most strongly associated with low vitamin D (15 things were evaluated) – July 2022
- Long-term Psoriasis cured by 30,000 to 60,000 IU of Vitamin D daily (pictures and video) – early 2022
- Psoriasis paradigm shift – use topicals, like Vitamin D – Aug 2021
- Low Vitamin D plus psoriasis equals 8 times more likely to die – Dec 2020
- UV has treated psoriasis for over a century, guidelines finally agreed upon – Aug 2019
- Psoriasis severity associated with low vitamin D (10 studies) – meta-analysis Jan 2018
- Psoriasis reduced for those getting Vitamin D levels above 50 ng – RCT Feb 2018
- 35,000 IU vitamin D daily for 6 months helped ALL psoriasis suffers (106 ng) – Brazil March 2013
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