Sleep Apnea and Vitamin D - many studies

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13+ VitaminDWiki pages have SLEEP APNEA in the title

This list is automatically updated

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13.8 X increased risk of Pediatric Obstructive Sleep Apnea if vitamin D deficient – Oct 2024

Vitamin D Deficiency and Pediatric Obstructive Sleep Apnea Severity
AJAMA Otolaryngol Head Neck Surg. 2024 Oct 31. doi: 10.1001/jamaoto.2024.3737. PDF behind paywall
ndrew E Bluher 1 2, Timothy Kearney 3, Turaj Vazifedan 4, Cristina M Baldassari 5 6 7

Importance: Prior research has demonstrated an association between vitamin D deficiency and obstructive sleep apnea (OSA) in adults; however, its association with pediatric OSA is emerging.

Objective: To evaluate the association of vitamin D levels with obstructive Apnea-Hypopnea Index (AHI) in children with OSA.

Design, settings, and participants: This was a cross-sectional study of children aged 2 to 16 years with severe obstructive OSA (AHI ≥20 on polysomnogram) who were undergoing adenotonsillectomy at a tertiary care pediatric otolaryngology clinic from 2017 to 2022. Age, sex, race, body mass index, history of asthma, and season were considered in the analyses. Data were analyzed from September 3, 2021, to October 8, 2021.

Main outcomes and measures: Serum 25-hydroxyvitamin D (25[OH]D) levels were measured and assessed for correlation with polysomnography metrics. Fasting blood samples were collected and vitamin D deficiency was defined as 25(OH)D level less than 20 ng/mL.

Results: The consecutive sample included 72 patients (mean [SD] age, 6.7 [3.9] years; 34 [47.2%] females and 38 [52.8%] males). The mean (SD) AHI was 42.8 (25.5), and 35 participants (49.0%) had obesity. Vitamin D deficiency was present in 27 participants (37.5%). In univariate analysis, vitamin D deficiency was associated with younger age (difference, -5.0; 95% CI, -7.2 to -2.8), Black race (odds ratio [OR], 4.3; 95% CI, 1.4 to 14.3), female sex (OR, 4.8; 95% CI, 1.7 to 12.5), and higher obstructive AHI (difference, 13.8; 95% CI, 1.2 to 26.4). In multivariable analysis, vitamin D deficiency remained significantly associated with AHI. A 1.0-unit decrease in serum 25(OH)D levels was associated with an AHI increase of 0.7 (95% CI, 0.04 to 1.40).

Conclusions: The findings of this cross-sectional study indicate that vitamin D deficiency was common in children undergoing adenotonsillectomy for severe OSA and is significantly associated with increased OSA severity. Future research is needed on vitamin D supplementation and its association with any improvements in pediatric OSA treatment outcomes.

Some details of the study are at MedPageToday

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Sleep Apnea and Vitamin D Deficiency - Mercola interview Gominak Feb 2024

86 minutes dual, connected epidemics: Low D, Sleep Apnea
 Transcript
Vitamin D is important for hibernation then should also be important for deep sleep
Vitamin D needed to stop movements (needed for deep sleep)
She has helped >5,000 people
Fit bits are very good at monitoring deep sleep
Vitamin D levels of 60-80 ng are needed if you do not have good B vitamins (oral or gut)
B vitamins are very important - only need 40-60 ng of Vitamin D
B vitamins also made by Microbiome - including gut
His notes on the video

• There’s a synergy between vitamin D deficiency and poor sleep, both of which are at epidemic proportions in many parts of the world.
• Lack of vitamin D causes impairment in your brain stem, which in turn can impair your sleep.
• Vitamin D is also a crucial component required to make acetylcholine, a neurotransmitter that allows you to get “paralyzed” so that deep sleep can occur.
• B vitamins also play an important role in sleep. Ideally, you need to normalize your gut microbiome so that your gut bacteria make all the B vitamins your body and brain need.
• To normalize your gut microbiome, maintain a vitamin D level of 40 ng/mL or higher and take a B50 or B100 supplement for three months.

See also Restless Legs Syndrome dramatically reduced by vitamin D, etc

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Review of Obstructive Sleep Apnea and Vitamin D - Feb 2024

Exploring the link between vitamin D deficiency and obstructive sleep apnea: A comprehensive review
Review J Sleep Res . 2024 Feb 27:e14166. doi: 10.1111/jsr.14166
Nan Yao 1, Chenyuan Ma 2, Ruixue Dou 3, Chao Shen 4, Ye Yuan 5, Wei Li 4, Jun Qu 1

Relevant Studies - presence and severity

Relevant Studies - risk

Despite the high prevalence and significant health burden of obstructive sleep apnea (OSA), its underlying pathophysiology remains incompletely understood. This comprehensive review explores the emerging connection between vitamin D deficiency and OSA, discusses potential mechanisms underlying this association, and explores the therapeutic implications of these findings. Recent research has consistently highlighted the high incidence of vitamin D deficiency among patients with OSA, which often occurs independently of geographical location. This suggests that factors beyond lack of sunlight exposure may be involved. This review also discusses how reduced vitamin D may be associated with more severe manifestations of OSA. In addition, it explores the potentiality of using vitamin D supplements as a therapeutic strategy for OSA, noting that some studies have found improvements in sleep quality and a reduction in OSA severity. Potential mechanisms are proposed, including the role of vitamin D deficiency in promoting inflammation, oxidative stress, hypoxia, impairing immune function, muscle function, and gene polymorphism of vitamin D receptors, all of which could contribute to the pathogenesis of obstructive sleep apnea. The paper underscores the need for future research to validate these observations, to determine optimal vitamin D supplementation dosage and duration, to explore potential side effects and risks, and to investigate potential interactions with other treatments.
 Download the PDF from VitaminDWiki

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Obstructive sleep apnea and vitamin D: an updated systematic review and meta-analysis – Sept 2023

Hormones (Athens). 2023 Sep 14. doi: 10.1007/s42000-023-00481-3
Huai Heng Loh 1 2, Quan Hziung Lim 3, Waye Hann Kang 4, Anne Yee 5, Mei Ching Yong 6, Norlela Sukor 7 8

PURPOSE : Obstructive sleep apnea (OSA) is a chronic, sleep-related breathing disorder which leads to increased cardiovascular risks. Vitamin D deficiency is associated with various cardiometabolic complications, including increased cardiovascular morbidity and mortality. We aimed to analyze the difference in serum 25-hydroxyvitamin D (25-OHD) level, prevalence of vitamin D insufficiency and deficiency, and the effect of CPAP treatment on serum 25-OHD levels among adult patients with OSA.

Methods: We pooled data from 18 observational studies involving 5592 individuals. Baseline parameters that might have contributed to the significant differences observed were also analyzed.

Results: Patients with OSA had significantly lower serum 25-OHD levels (pooled d + - 0.74 [95% CI: - 1.19 to - 0.28], p < 0.01) and higher prevalence of vitamin D deficiency (pooled log (odds ratio) 0.98 [95% CI: 0.30 to 1.67], p < 0.01) compared to those without OSA. Subgroup analysis demonstrated that these differences were significant only in moderate OSA and severe OSA. Neither age nor BMI nor geographical latitude contributed significantly to the differences observed in serum 25-OHD levels. The use of CPAP did not lead to significant changes in serum 25-OHD levels.

Conclusion: Patients with OSA have lower serum 25-OHD levels with a higher prevalence of vitamin D deficiency, regardless of age or BMI, pointing to an independent association between vitamin D and OSA.

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10% of Americans have sleep apnea (but only half are aware of it)

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