Newly-identified Pathways Relating Vitamin D to Carcinogenesis: A Review
In Vivo May 2021, 35 (3) 1345-1354; DOI: https://doi.org/10.21873/invivo.12387
NADEEM BILANI, LEAH ELSON, CHARLES SZUCHAN, ELIZABETH ELIMIMIAN, MUSTAFA SALEH and ZEINA NAHLEH
Cancer category starts with the following
- Cancer 303 items Overview Cancer and vitamin D
- Cancer and Vitamin D - many studies
- After Cancer Diagnosis 117 items
- Bladder Cancer 28 items
- Breast Cancer 263 items Overview Breast Cancer and Vitamin D
- Colon Cancer 147 items Overview Cancer-Colon and vitamin D
- Leukemia 19 items
- Liver Cancer 17 items
- Lung Cancer 56 items Overview Lung cancer and vitamin D
- Lymphoma Cancer 26 items
- Other Cancer 68 items
- Ovarian Cancer 26 items
- Pancreatic Cancer 59 items
- Prostate Cancer 106 items Overview Prostate Cancer and Vitamin D
- Skin Cancer 121 items Overview Suntan, melanoma and vitamin D
- Childhood Cancers - Vitamin D can help - many studies
- Easiest way to treat cancer – take Vitamin D – Nov 2022
- 13 Cancers are helped by Vitamin D – Biobank July 2023
- 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
- Vitamin D prevents and treats cancer in many ways – May 2021
- Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer stem cells and Vitamin D - many studies
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
The review on this page does not appear to mention the Vitamin D Receptor. which is very important in many Cancers
Download the PDF from VitaminDWiki
Background: The epidemiological relationship between vitamin D levels and cancer has been thoroughly investigated. Published data from large studies appear to corroborate a significant relationship between higher serum vitamin D concentrations and improved survival. Mechanistic reviews on commonly-studied cancers – including breast cancer, colon cancer and melanoma – focus predominantly on data from older studies. In outlining avenues for future research, we believe there is utility in summarizing novel findings introduced to the literature.
Materials and Methods: In this narrative review, we used MEDLINE, PUBMED and Cochrane databases to identify mechanistic studies published from January 1, 2015 onwards exploring this topic.
Results: Twenty-five mechanistic studies were included in this review. It was found that vitamin D plays a critical role in both
- direct
- tumor gene expression, proliferation, invasiveness, sensitivity to chemotherapy etc. and
- indirect
- effects on the tumor microenvironment and immunomodulation)
tumor suppression mechanisms.
Conclusion: These newly-identified pathways warrant further research, with the hopes that we may understand how and when vitamin D supplementation can be integrated into precision medicine therapeutics for cancers of the breast, colon and skin. Cancer care providers should consider recommendations to screen for vitamin D deficiency in this population.