Fracture risk in systemic lupus erythematosus patients over 28 years
Rheumatology (Oxford). 2020 Nov 22;keaa705. doi: 10.1093/rheumatology/keaa705
Daniela Garelick 1, Sara Moreira Pinto 2, Filipa Farinha 3, Tatiana Pires 4, Emon Khan 3, David Isenberg 3
Note: No statistically increased fracture risk with Lupus is not a surprise since 93% were taking Vitamin D
Falls and Fractures category contains the following
258 items in FALLS and FRACTURES - Vitamin D and Calcium cost-effectively reduce falls and fractures – April 2019
- see also Overview Seniors and Vitamin D
Falls
- Fall prevention - Vitamin D is one of the ways - umbrella review Jan 2024
- Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019
- Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
- Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
- Falls reduced by a third if achieved 40 ng level vitamin D– RCT Sept 2018
- Note: It took 6 months to get to that level. Most trials last only 3 months
- Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
- Falls reduced by Vitamin D: 13 percent reduction if more than 700 IU – review of 38 trials – Aug 2022
Fracture
- Hip fractures are predicted by 10 factors – low Vitamin D is the biggest – Aug 2023
- Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Vitamin K (any amount and any kind) reduced bone fractures by 24 percent – meta-analysis – May 2019
- 75+ Hip fracture items in VitaminDWiki title Click here for details
Increased use of D has the following
People have been noticing, and increasing vitamin D (55 items) Studies are showing increased Vitamin D consumption and associated
Increased levels of vitamin D PLUS increased health- Vitamin D is increasing in Greece: testing, supplementation, and levels – Jan 2024
- US Vitamin D levels increased 2001-2018 – Oct 2022
- After years of adding vitamin D, Finland now has 38 ng levels - March 2022
- Trends in vitamin D status around the world – Nov 2021
- Vitamin D levels increased in Saudi Arabia over a decade (more sun or supplements) – Sept 2021
- 26 X increase in Vitamin D prescriptions for youths in England in 8 years – Dec 2019
- Vitamin D levels continue to rise in the US - April 2019
- 93 pcnt of these Lupus patients supplemented with Vitamin D - Nov 2020
- UK people with Multiple Sclerosis are 3X more likely to take Vitamin D - Oct 2020
- Parkinson patients: 60 % taking Vitamin D – Dec 2019
- The use of Vitamin D to prevent prostate cancer doubled in a decade – May 2019
- Vitamin D levels continue to rise in the US - April 2019
- Vitamin D levels at Mayo Clinic increased over a decade – June 2018
- Vitamin D levels in US: percent having more than 40 ng doubled (2001-2010) - Dec 2016
- Rickets almost eradicated in counties giving free Vitamin D, perhaps the world can learn – Dec 2019
- Vitamin D in US children: those having more than 40 ng increased 60 percent (2001-2010) - Dec 2016
- 4 times fewer with vitamin D deficiency in just 4 years ( Connecticut) – March 2016
- 20X increase in vitamin D sold and 36 percent decrease in osteoporosis business in Australia – Nov 2013
- Many more people now have vitamin D levels above 50 ng, especially seniors – May 2015
- has the following chart for one US county
Objectives: Chronic glucocorticoid use is complicated by osteoporosis and increases the risk of fragility fractures. EULAR guidelines on SLE management recommend reducing chronic glucocorticoid dosage to ≤7.5 mg/day to minimize this risk. We examined the relationship of glucocorticoid dose to fragility fracture risk in a cohort of SLE patients.Methods: Retrospective analysis of SLE patients attending University College Hospital over 28 years was undertaken. Collected data included consecutive steroid dose, dual-energy X-ray absorptiometry scans and fragility fractures.
Results: We collected data on 250 patients with a median of 17 years' follow-up. Fragility fractures were diagnosed in 28 (11.2%) patients and the mean ± s.d. age of first fracture was 51 ± 16 years. A total of 94% received glucocorticoids, the average dose being 6.20 mg/day. Patients with fragility fractures had a lower average daily dose (5.36 vs 6.23 mg/day) but a higher median cumulative dose (25.19 vs 20.96 g). These differences were not significant (P = 0.127 and 0.229, respectively). Some 93% of patients received vitamin D, and 85% received calcium. Cox regression analysis showed older age at SLE diagnosis, osteoporosis and secondary hyperparathyroidism were associated with fragility fractures. Glucocorticoid dose was not significantly associated with the occurrence of fragility fractures. Twenty-two patients with fractures were treated with bisphosphonates, two with denosumab and two with teriparatide.
Conclusions: We found no significant association between glucocorticoid treatment and fragility fractures in our group of patients; however, a prospective study including more patients not treated with CS would be necessary to confirm these results.
93 pcnt of these Lupus patients supplemented with Vitamin D - Nov 2020Printer Friendly Follow this page for updates3886 visitors, last modified 05 Sep, 2021, This page is in the following categories (# of items in each category)