High Omega-3 reduced risk of Ischemic stroke by 18% - Dec 2023

---

Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

Stroke. 2024;55:50–58 https://doi.org/10.1161/STROKEAHA.123.044281
James H. O’Keefe, Nathan L. Tintle, William S. Harris, Evan L. O’Keefe, Aleix Sala-Vila, John Attia, G. Manohar Garg, Alexis Hure, …

BACKGROUND:
The effect of marine omega-3 PUFAs on risk of stroke remains unclear.

METHODS:
We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome.

RESULTS:
Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76–0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74–0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81–0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78–0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD.

CONCLUSIONS:
Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.
 Download the PDF from VitaminDWiki

---

See discussion at Grassrootshealth

---

VitaminDWiki - 18 studies in both categories Omega-3 and Inflammation

This list is automatically updated

---

VitaminDWiki - Omega-3 helps many health problems

411 Omega-3 items in category Omega-3 helps with: Autism (7 studies), Depression (28 studies), Cardiovascular (34 studies), Cognition (52 studies), Pregnancy (46 studies), Infant (34 studies), Obesity (14 studies), Mortality (7 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
CIlck here for details

---

VitaminDWiki - Overview: Omega-3 many benefits include helping vitamin D

(411) items in category Omega-3 and Vitamin D

• Omega-3 reduces risk of COVID-19 - many studies
• Cardiovascular problems reduced by Omega-3 - many studies
• Omega-3 helps muscles - many studies
• Omega 3 increases vitamin D in the blood – many studies
• Omega-3 index - many studies
• Omega-6 blocks Omega-3 etc. -many studies
• Omega-6 increase may have increased the risk of many diseases - Jan 2022
• Preterm birth decreased by Omega-3, etc. - many studies
• Omega-3 reduces many psychiatric disorders – 2 reviews 2016
• ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
• Schizophrenia relapses reduced 3X by Omega-3 – RCT Mar 2015
• Typical pregnancy is now 39 weeks – Omega-3 and Vitamin D might restore it to full 40 weeks
• Omega-3 supplementation during pregnancy reduce early preterm births (save 1500 USD per child) – Aug 2016
• Infants getting 1 g of Omega-3 for 12 weeks got better brains – RCT March 2017
• Omega-3 conference and 12 publications – Nov 2014
• Vitamin D Cofactors in a nutshell by VitaminDWiki
• For every Omega-3 dollar there is a 84 dollar savings in Cardiovascular costs - Foster and Sullivan April 2016
• Overweight women on caloric restriction diet got 3X benefits from 8 weeks of Omega-3 – RCT Dec 2015
• 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
• Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
• Omega-7 - in addition to Omega-3
• Consuming more monounsaturated fat increased vitamin D – Aug 2011 has the following
  WikiPedia Good (more vitamin D into bloodstream)= much more BLUE than Green

Almonds and macadamia nuts are examples of good foods to take with vitamin D

---

23+ VitaminDWiki Stroke pages have ISCHEMIC OR ISCHAEMIC in the title

This list is automatically updated