Table of contents
- Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA)
- VitaminDwiki - Lupus contains
- VitaminDWiki - 8 studies in both categories Lupus and Intervention
- VitaminDWiki 6 studies in both categories Lupus and Vitamin D Receptor
Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA)
PLoS One. 2022 Jun 29;17(6):e0270569. doi: 10.1371/journal.pone.0270569
Keigo Hayashi 1, Ken-Ei Sada 1 2, Yosuke Asano 1, Yu Katayama 1, Keiji Ohashi 1, Michiko Morishita 1, Yoshia Miyawaki 1, Haruki Watanabe 1, Takayuki Katsuyama 1, Mariko Narazaki 1, Yoshinori Matsumoto 1, Nobuyuki Yajima 3 4, Ryusuke Yoshimi 5, Yasuhiro Shimojima 6, Shigeru Ohno 7, Hiroshi Kajiyama 8, Kunihiro Ichinose 9, Shuzo Sato 10, Michio Fujiwara 11, Jun Wada 1
Why did they bother to write the article when they did not know how much Vitamin D was given?
Background: Although vitamin D concentration is reportedly associated with the pathogenesis and pathology of systemic lupus erythematosus (SLE), benefits of vitamin D supplementation in SLE patients have not been elucidated, to our knowledge. We investigated the clinical impacts of vitamin D supplementation in SLE.
Methods: A cross-sectional analysis was performed using data from a lupus registry of nationwide institutions. We evaluated vitamin D supplementation status associated with disease-related Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) as a parameter of long-term disease activity control.
Results: Of the enrolled 870 patients (mean age: 45 years, mean disease duration: 153 months), 426 (49%) received vitamin D supplementation. Patients with vitamin D supplementation were younger (43.2 vs 47.5 years, P < 0.0001), received higher doses of prednisolone (7.6 vs 6.8 mg/day, P = 0.002), and showed higher estimated glomerular filtration rates (79.3 vs 75.3 mL/min/1.73m2, P = 0.02) than those without supplementation. Disease-related SDI (0.73 ± 1.12 vs 0.73 ± 1.10, P = 0.75), total SDI, and SLE Disease Activity Index (SLEDAI) did not significantly differ between patients receiving and not receiving vitamin D supplementation. Even after excluding 136 patients who were highly recommended vitamin D supplementation (with age ≥ 75 years, history of bone fracture or avascular necrosis, denosumab use, and end-stage renal failure), disease-related SDI, total SDI, and SLEDAI did not significantly differ between the two groups.
Conclusions: Even with a possible Vitamin D deficiency and a high risk of bone fractures in SLE patients, only half of our cohort received its supplementation. The effect of vitamin D supplementation for disease activity control was not observed.
Download the PDF from VitaminDWiki
VitaminDwiki - Lupus contains
80 items in LUPUS categorySome of the studies in VitaminDWiki
- Every aspect of Lupus is associated with low viramin D – Oct 2021
- It is time to routinely give vitamin D to Lupus patients – Dec 2016
- 93 pcnt of these Lupus patients supplemented with Vitamin D - Nov 2020
- Lupus patients are 5 X more likely to have low vitamin D – many meta-analyses
- Lupus fought by Vitamin D in all trials longer than 12 weeks - review Sept 2017
Autoimmune disease, mainly in 50 per 100,000 women, no cure, many parts of body Wikipedia
VitaminDWiki - 8 studies in both categories Lupus and Intervention
This list is automatically updated
- Lupus treated again by daily Vitamin D - 4,000 IU or 8,000 IU (slightly better) - RCT Feb 2025
- Lupus: 60,000 IU Vitamin D monthly got to only 34 ng, not enough to help – RCT Jan 2023
- Lupus reduced when half of participants got to 38 ng of Vitamin D (not statistically significant) – RCT Jan 2017
- Juvenile Lupus fatigue reduced by vitamin D ( 50,000 IU weekly for 6 months) – RCT May 2015
- Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT April 2015
- Lupus reduced with vitamin D intervention – Feb 2014
- Lupus flareups cut in half by just 2,000 IU of vitamin D – RCT Dec 2012
- Lupus flares totally eliminated by loading dose then 100000 IU of vitamin D each month – Oct 2012
VitaminDWiki 6 studies in both categories Lupus and Vitamin D Receptor
This list is automatically updated
- Lupus 3.8 X more likely if a poor Vitamin D Receptor – May 2019
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Lupus in children 2.6 X more likely if they had poor Vitamin D Receptor – Jan 2017
- Lupus associated with both low vitamin D and Vitamin D receptor problems – April 2016